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- 2025年12月05日
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货期：1-2天
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MedChemExpress LLC
- CAS号：
161068-53-7
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1 mg
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Epimedokoreanin B
CAS No. : 161068-53-7
MCE 国际站：Epimedokoreanin B
产品活性：Epimedokoreanin B 是一种天然黄酮类化合物，具有抗癌、抗炎和抗菌作用。Epimedokoreanin B 通过内质网应激介导的伴随自噬体积聚的细胞凋亡 (apoptosis) 抑制肺癌细胞的生长。Epimedokoreanin B 是一种抗牙周炎剂，可抑制牙龈蛋白酶和牙龈卟啉单胞菌的生长和生物膜形成。
研究领域：Anti-infection | Apoptosis
In Vitro: Epimedokoreanin B (compound6; 3.13-25 μM; 48 hours) shows significate inhibitory effect on proliferation against lung cancer cell A549, Calu1 and H1299. Epimedokoreanin B displays no toxic on human bronchial epithelial cells BEAS-2B.Epimedokoreanin B treatment inhibits cell proliferation and migration accompanied by cytoplasmic vacuolation in A549 and NCI-H292 cells. Atophagosome accumulation accompanied with autophagy flux blocking is observed in Epimedokoreanin B treated cells, this was consistent with the occurrence of ER stress.
Epimedokoreanin B (5 μM; 24 hours) inhibits CD163 expression and IL-10 production, which are known M2 markers, suggesting that Epimedokoreanin B inhibits M2 polarization in human monocyte-derived macrophages (HMDMs). Epimedokoreanin B suppresses STAT3 activation in HMDMs.
In Vivo: Epimedokoreanin B (20 mg/kg; p.o; thrice a week; for 17 days) inhibits tumor growth in an LM8 tumor-bearing murine model.
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