Simlukafusp alfa,1776942-10-9

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Simlukafusp alfa

CAS No. : 1776942-10-9

MCE 国际站：Simlukafusp alfa

产品活性：Simlukafusp alfa (FAP-IL2v) 是一种免疫细胞因子，包括一种抗成纤维细胞活化蛋白 α (FAPα) 的抗体和一种只结合 IL-2Rβγ 的 IL-2 变体。Simlukafusp alfa 是一种人 IgG1 抗体。

研究领域：Immunology/Inflammation

作用靶点：Interleukin Related

In Vitro: Simlukafusp alfa (FAP-IL2v) shows binding affinity constants of 43±9 pM, 80±20 pM, 660±80 pM, 0.3 nM, 0.23 nM and 0.5 nM with huIL-2Rβγ, cyIL-2Rβγ, muIL-2Rβγ, huFAP, cyFAP and muFAP, respectively.
Simlukafusp alfa (0-100 nM; 5 days) activates CD4+/CD8+ T cells and NK cells in vitro, but not preferentially Tregs.
Simlukafusp alfa (0-100 nM) enhances Cetuximab (HY-P9905)-mediated antibody-dependent cellular cytotoxicity (ADCC) and Cibisatamab (HY-P99011)-mediated T-cell-dependent cellular cytotoxicity (TDCC) in vitro.

In Vivo: Simlukafusp alfa (FAP-IL2v) (1 mg/kg; i.v.; weekly for 4 weeks) is efficacious in combination with therapeutic antibodies in murine models of human cancer.

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