Antiproliferative agent-17

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Antiproliferative agent-17

CAS No. : 2882206-08-6

MCE 国际站：Antiproliferative agent-17

产品活性：Antiproliferative agent-17 是一种抗增殖剂。Antiproliferative agent-17 抑制革兰氏阳性菌并具有抗癌活性。

研究领域：Anti-infection  |  Epigenetics  |  Cell Cycle/DNA Damage

作用靶点：Bacterial  |  Sirtuin

In Vitro: Antiproliferative agent-17 (compound 5e) shows activity against the Gram-positive bacteria Staphylococcus aureus IFO 3060, Bacillus subtilis IFO 3007 and Micrococcus luteus IFO 3232. Antiproliferative agent-17 has no activity against the tested Gram-negative bacteria and fungi.
Antiproliferative agent-17 (compound 5e) displays anti-proliferative activity with IC₅₀ values of 12.85 μM, 11.96 μM, 16.30 μM, 9.87  μM, and 6.90 μM for PC-3 (human prostate cancer), HCT-116 (human colorectal cancer), HepG-2 (human hepatocellular cancer), HeLa (human cervical cancer), and MCF-7 (human breast cancer), respectively.
Antiproliferative agent-17 (compound 5e) binds to the active site of the SIRT1 enzyme, occupying the positions of the NAD cofactor and the known histone deacetylase inhibitor EX527.

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