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- 保存条件：
4°C, protect from light
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货期：1-2天
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MedChemExpress LLC
- CAS号：
1260247-42-4
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2335.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1200.0 |
| 规格： | 5 mg | 产品价格： | ￥3500.0 |
| 规格： | 10 mg | 产品价格： | ￥5800.0 |
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LLL12
CAS No. : 1260247-42-4
MCE 国际站：LLL12
产品活性：LLL12 是一种 STAT3 小分子抑制剂，抑制 STAT3 磷酸化。LLL12 增强顺铂 (HY-17394) 和紫杉醇 (HY-B0015) 对卵巢癌症细胞生成、迁徙、和生长的抑制作用。
研究领域：JAK/STAT Signaling | Stem Cell/Wnt
作用靶点：STAT
In Vitro: LLL12 (0.01-1 μM; 72 h) inhibits cell viability of ovarian cancer cell lines with or without Cisplatin (0.5 μM, 2.5 μM) and Paclitaxel (0.25 μM, 0.5 μM)..
LLL12 (0.25-1.0 μM; 72 h) inhibit STAT3 phosphorylation (Tyr705) in ovarian cancer cell lines.
In Vivo: LLL12 (5 mg/kg; i.p.; once daily for 13 d) shows strong growth inhibition activity in mouse osteosarcoma cells and tumor growth.
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文献和实验blades; Roboz, cat. no. RS‐5913) 1 Small tube or thin gauze roll (∼12 × 75 mm) Gaymar TP500 water pump for heated bed
[实验原理] 碱裂解法提取质粒利用的是共价闭合环状质粒DNA与线状的染色体DNA片段在拓扑学上的差异来分离它们。在pH值介于12.0-12.5这个狭窄的范围内，线状的DNA双螺旋结构解开变性，在这样的条件下，共价闭环质粒DNA的氢键虽然断裂，但两条互补链彼此依然相互盘绕而紧密地结合在一起。当加入pH4.8的醋酸钾高盐缓冲液使pH降低后，共价闭合环状的质粒DNA的两条互补链迅速而准确地复性，而线状的染色体DNA的两条互补
for storing and describing biomolecular interactions, molecular complexes and pathways. Bioinformatics, 16(5):465-77. 11• Baldi P and Brunak S.2001.Bioinformatics: the Machine Learning Approach.MIT Press. 12• Bar-Joseph Z, Gerber G, Simon I, Gifford DK
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