Anti-ZDHHC21 Polyclonal Antibo

产品简介

靶标	ZDHHC21
别名	DHHC-21;DNZ1;EC 2.3.1;EC 2.3.1.-;HSPC097;probable palmitoyltransferase ZDHHC21;Zinc finger DHHC domain-containing protein 21;zinc finger, DHHC domain containing 21;zinc finger, DHHC-type containing 21,9130404H11Rik;
背景资料	Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:22031296). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane (PubMed:22031296). This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (PubMed:22031296). Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation. Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium. Has also a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction. May also palmitoylate eNOS and LCK (By similarity).
Swiss Prot	Q8IVQ6
Gene ID	340481
宿主	Rabbit
克隆类型	Polyclonal Antibody
亚型	IgG
预测交叉反应	Chimpanzee;Cow
蛋白分子量	31kDa
实际分子量	35kDa
稀释比例	WB 1:1000-3000. IHC 1:50-200.
免疫原	A synthetic peptide of human ZDHHC21
Public Immunogen Range	50-100/265aa
纯化方法	Affinity purification
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
保存	Store at -20℃. Avoid freeze / thaw cycles.
交叉反应	Human Mouse
应用	WB IHC
规格	50ul 100ul
单位	支

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示：
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图

Immunohistochemistry of paraffin-embedded human colorectal cancer with ZDHHC21 antibody diluted at 1:100.

Western blot analysis with ZDHHC21 antibody diluted at 1:2000;Lane: HeLa,U-87.