Yes, in ALS treatedBALB/cmice, forms poorly differentiated adenocarcinoma(gradeIII).Yes,innude mice, forms poorly differentiated adenocarcinoma(grade III).
melanoma patients refractory/nonresponding to PD-1 blockade.Results: Domatinostat increased the expression of antigen-presenting machinery (APM) genes and MHC class I and II molecules, along with CTL infiltration, in tumors of both immune phenotypes. In combination with PD-(L)1 blockade, domatinostat augmented antitumor effects substantially above the effects of
melanoma patients refractory/nonresponding to PD-1 blockade.Results: Domatinostat increased the expression of antigen-presenting machinery (APM) genes and MHC class I and II molecules, along with CTL infiltration, in tumors of both immune phenotypes. In combination with PD-(L)1 blockade, domatinostat augmented antitumor effects substantially above the effects of