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说明书
说明书
说明书
多克隆
Rabbit
说明书
BRCC3
乳腺癌易感基因复合物亚基蛋白3抗体
Unconjugated
说明书
说明书
KLH conjugated synthetic peptide derived from human BRCC3/BRCC36
LgG
液体
说明书
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
1mg/ml
100ul
产品名称:乳腺癌易感基因复合物亚基蛋白3抗体 英文名称:BRCC3 英文别名:BRCA1-A complex subunit BRCC36; BRCA1/BRCA2 containing complex subunit 3; BRCA1/BRCA2 containing complex subunit 36; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; Brcc3; BRCC3_HUMAN; BRCC36; BRISC complex subunit BRCC36; C6.1A; Chromosome X open reading frame 53; CXorf53; Lys-63-specific deubiquitinase BRCC36. 交叉反应: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep 标记: Unconjugated 抗体来源: Rabbit 抗体类型: Polyclonal 免疫原: KLH conjugated synthetic peptide derived from human BRCC3/BRCC36 蛋白细胞定位: 细胞核 纯化方法: affinity purified by Protein A 亚型: IgG 性状: Liquid 浓度: 1mg/ml 储存液: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件: Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. 背景资料: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. |
产品名称 | 浓度 | 型号 |
乳腺癌易感基因复合物亚基蛋白3抗体 | 1mg/ml | EY-01K4844 |
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