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文献和实验Preparation and Atomic Force Microscopy of Quadruplex DNA
The purpose of this chapter is to provide detailed instructions for the preparation and atomic force microscopy (AFM) imaging of linear chains of quadruplex DNA (a.k.a. “G-wire DNA”). Successful self-assembly of long chain quadruplex DNA
G-Quadruplex Structures and G-Quadruplex-Interactive Compounds
G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. DNA G-quadruplexes have recently emerged as attractive cancer therapeutic targets. It has been shown that the 3′ G-rich
Quantifying Interactions Between G-Quadruplex DNA and Transition-Metal Complexes
Telomerase inhibition through guanine quadruplex sequestration by small-molecule drugs is of great current interest as an anticancer strategy. G-quadruplexes (GQs) can be formed at the guanine-rich sequences found at the end of the telomere
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