SHIN 1

SHMT1和SHMT2抑制剂（IC50分别为5和13nM）；抑制过表达FRAT1的H1299 NSCLC细胞增殖（IC50=0.6µM）；使用FRAT1过表达的H1299细胞，每周三次，每次100mg/kg，减少NSCLC小鼠异种移植模型中的肿瘤体积。An SHMT1 and SHMT2 inhibitor (IC50s = 5 and 13 nM, respectively); inhibits proliferation of H1299 NSCLC cells overexpressing FRAT1 (IC50 = 0.6 µM); decreases tumor volume in an NSCLC mouse xenograft model using FRAT1-overexpressing H1299 cells at 100 mg/kg three times a week.分子式C24H24N4O2分子量400.5N#CC1=C(N)OC2=C(C1(C(C)C)C3=CC(CO)=CC(C4=CC=CC=C4)=C3)C(C)=NN2