Chicago Sky Blue 6B

一种具有多种生物活性的谷氨酸染料和衍生物；0.1mM时可抑制大鼠脑突触小泡(Ki=0.19µM)对谷氨酸的吸收，但不抑制突触体；CaMKP和CaMKP-N的抑制剂（IC50s分别为4.1和1µM）；对CaMKP和CaMKP-N的选择性优于PP2C和钙调神经磷酸酶，10µM时对后者的抑制率分别低于10%和20%；NTCP的抑制剂（IC50=7.1µM）；17µM时可降低HepaRG细胞中的HBV和HDV感染；0.5µg时可抑制小鼠的炎症疼痛和热痛觉过敏。A dye and derivative of glutamate with diverse biological activities; inhibits glutamate uptake by rat brain synaptic vesicles (Ki = 0.19 µM) but not synaptosomes at 0.1 mM; an inhibitor of CaMKP and CaMKP-N (IC50s = 4.1 and 1 µM, respectively); selective for CaMKP and CaMKP-N over PP2C and calcineurin, which it inhibits by less than 10 and 20%, respectively, at 10 µM; an inhibitor of NTCP (IC50 = 7.1 µM); reduces HBV and HDV infection in HepaRG cells at 17 µM; inhibits inflammatory pain and thermal hyperalgesia in mice at 0.5 µg.分子式C34H24N6O16S4 • 4Na分子量992.8COC1=CC(C2=CC=C(C(OC)=C2)/N=N/C(C=CC3=C(S([O-])(=O)=O)C=C4S([O-])(=O)=O)=C(O)C3=C4N)=CC=C1/N=N/C(C=CC5=C(S([O-])(=O)=O)C=C6S([O-])(=O)=O)=C(C5=C6N)O.[Na+].[Na+].[Na+].[Na+]