Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
适应物种:
Human
保质期:
12个月
库存:
现货
宿主:
Rabbit
应用范围:
WB, IHC, ICC/IF, FC, IP
靶点:
FADD
规格:
20μL/50μL/100μL
规格:
20μL
产品价格:
¥850.0
规格:
50μL
产品价格:
¥1400.0
规格:
100μL
产品价格:
¥2400.0
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]