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Survivin (8B9) Mouse mAb

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  • ¥1400 - 2400
  • 戴格
  • db6518
  • 2025年11月16日
  • WB,IHC-P
  • Mouse
  • Human, Rat
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  • 企业认证

    • 详细信息
    • 文献和实验
    • 技术资料
    • 保存条件

      Store at -20°C. Supplied in PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Stable for 12 months from date of receipt.

    • 适应物种

      Human, Rat

    • 保质期

      12个月

    • 库存

      现货

    • 宿主

      Mouse

    • 应用范围

      WB,IHC-P

    • 靶点

      Survivin

    • 规格

      50μL/100μL

    规格:50μL产品价格:¥1400.0
    规格:100μL产品价格:¥2400.0
    Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed/9859993, PubMed/21364656, PubMed/20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed/16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed/20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed/20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed/18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed/9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed/20826784). May play a role in neoplasia (PubMed/10626797). Inhibitor of CASP3 and CASP7 (PubMed/21536684). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed/12773388, PubMed/16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed/10626797).

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    图标文献和实验
    相关实验
    • Purification of mAb (IgG)

      (adjust pH to 7.8 with Binding buffer; red color) to the Protein A column.Mouse antibodies of the IgG1 subclass do not have a high affinity for protein A. Purification on protein A beads using standard conditions will yield approximately 1/10

    • Purification of mAb (IgG)

        Purification of mAb (IgG) by Chang-Duk Jun, 03/14/2000 Purpose Materials Antibody 7E3 , 2L sup grown in flasks, frozen and thawed overnight. BioRad Affi-Gel Protein A MAPS II Buffers

    • T-Cell Activation Using mAb to CD3

      One of the most common ways to assess T cell activation is to measure T cell proliferation upon in vitro stimulation of T cells via antigen or agonistic antibodies to TCR. This protocol is written as a starting point for examining in vitro proliferation of mouse

    图标技术资料

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