Dehydromiltirone去氢丹参新酮,116064-

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Dehydromiltirone

CAS No. : 116064-77-8

MCE 国际站：Dehydromiltirone

产品活性：Dehydromiltirone (1,2-Didehydromiltirone) 是一种具有抗炎作用的二萜醌。Dehydromiltirone 通过修饰 MAPK 和 NF-κB 信号通路、减少神经炎症反应和抑制血小板聚集来预防肝损伤。Dehydromiltirone 可用于骨质疏松症研究。

研究领域：NF-κB  |  MAPK/ERK Pathway

作用靶点：NF-κB  |  p38 MAPK

In Vitro: Dehydromiltirone (100 μg/mL; for 24 h) inhibits p38 and NF-κB signaling in Kupffer cells.
Dehydromiltirone inhibits the expression of osteoclast-associated genes, including NFATc1, CTSK, c-Fos, Acp5, and MMP9; and the phosphorylation of P38, ERK, and JNK of the MAPK signaling pathway; and the degradation of IκB-α of NF-κB signaling pathway. Dehydromiltirone exhibits an anti-osteoclastogenesis effect by reducing the expression of related genes, ultimately inhibiting bone resorption in vitro.

In Vivo: Dehydromiltirone (50-200 mg/kg, p.o.; daily; for five consecutive days) protects the liver from CCl4-induced injury. Dehydromiltirone reduces the increase in the proinflammatory cytokines TNF-α, IL-1 and IL-6, indicating an effect on alleviating liver inflammation.

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