AChE/Nrf2 modulator 1,2417117-

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

AChE/Nrf2 modulator 1

CAS No. : 2417117-84-9

MCE 国际站：AChE/Nrf2 modulator 1

产品活性：AChE/Nrf2 modulator 1 是乙酰胆碱酯酶 (AChE) /核因子红系 2 相关因子 2 (Nrf2) 调节剂，具有口服活性。AChE/Nrf2 modulator 1 具有 Nrf2 诱导活性和 AChE 抑制活性，对 eeAChE 和 hAChE 的 IC₅₀ 值分别为 0.07 μM 和 0.38 μM。AChE/Nrf2 modulator 1 可用于阿尔茨海默病的研究。

研究领域：Neuronal Signaling  |  NF-κB

作用靶点：Cholinesterase (ChE)  |  Keap1-Nrf2

In Vitro: AChE/Nrf2 modulator 1 (Compound 15a) has significant Nrf2 inductivity and excellent AChE inhibitory for eeAChE and hAChE with IC₅₀ values of 0.07 μM and 0.38 μM, respectively.
AChE/Nrf2 modulator 1 (5, 20 μM; 5-12 h) upregulates the protein and transcription level of Nrf2 and the downstream proteins HO1, NQO1, and GCLM and promotes Nrf2 translocation from cytoplasm into nuclei.
AChE/Nrf2 modulator 1 (1, 2.5, 5, 10, 20, 40 μM) exhibits important neuroprotective function in protecting the cells from being damaged by H202 and Aβ1-42 aggregation and exertes antioxidant stress and anti-inflammatory activities in reducing the production of ROS and pro-inflammatory cytokines.

In Vivo: AChE/Nrf2 modulator 1 (Compound 15a) (oral; 10 mg/kg; for 10 consecutive days) effectively shortens the latency time and escape distance to the target, increased the arrival times, and simplified the tracks in Morris water maze test induced by scopolamine and Aβ1-42.
AChE/Nrf2 modulator 1 (10, 20 mg/kg; intragastric administration) significantly reduces the levels of proinflammatory factors in the mice model brains.

相关产品：ML385  |  Resveratrol  |  Curcumin  |  4-Octyl itaconate  |  Sulforaphane  |  TBHQ  |  Luteolin  |  Dimethyl fumarate  |  Bardoxolone methyl  |  Omaveloxolone  |  KI696  |  Brusatol  |  Ezetimibe  |  Oltipraz  |  Carnosol  |  Hinokitiol  |  Donepezil Hydrochloride  |  Benzbromarone  |  α-NETA  |  ML334  |  TMPyP4 tosylate  |  CBR-470-1  |  Galanthamine  |  Garcinol  |  Physostigmine salicylate  |  Mangiferin  |  Scopoletin  |  Astilbin

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds