ONO-8711 dicyclohexylamine

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ONO-8711 dicyclohexylamine

CAS No. :

MCE 国际站：ONO-8711 dicyclohexylamine

产品活性：ONO-8711 dicyclohexylamine 是一种有效的选择性竞争性 EP1 拮抗剂，对人和小鼠 EP1 的 K_i 值分别为 0.6 nM 和 1.7 nM。ONO-8711 dicyclohexylamine 有效降低结肠癌、乳腺癌和口腔癌小鼠模型的肿瘤发生率。

研究领域：GPCR/G Protein

作用靶点：Prostaglandin Receptor

In Vitro: ONO-8711 (10 and 30 μM; 30 min) blocks the contractions induced by sulprostone in human pulmonary veins in a non-competitive manner.
ONO-8711 inhibits PGE₂-induced increase in cytosolic Ca²⁺ concentration with IC₅₀s of 0.21 μM, 0.05 μM, and 0.22 μM for the mouse, human, and rat receptors, respectively.

In Vivo: ONO-8711 (400 or 800 p.p.m.; p.o.; for 20 weeks) suppresses cancer incidence and delays occurrence of breast tumors.

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