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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
零下80~20°C
- 保质期:
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名:
Human PD-L1 inhibitor II
- 库存:
10
- 供应商:
TargetMol
- CAS号:
2135542-85-5
- 规格:
5 mg
Product Introduction
Bioactivity
英文名:Human PD-L1 inhibitor II
描述:Human PD-L1 inhibitor II is a potent PD-L1 inhibitor with anti-cancer activity.

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文献和实验药,就是通过阻断 PD-1 与其受体的结合,重新激活免疫系统来攻击肿瘤细胞[6]。为何要检测 PD-L1?PD-L1 组成性低表达于抗原递呈细胞(APCs)、非造血细胞如血管内皮细胞、胰岛细胞以及免疫豁免部位(如胎盘、睾丸和眼睛)。炎性细胞因子如 I/II 型干扰素、TNF-α和 VEGF 等均可以诱导 PD-L1 的表达[7]。大量研究表明,在癌症患者的样本中,PD-L1 在很多情况下呈现高表达趋势[8]。在肿瘤微环境中,免疫抑制分子如 PD-L1 的高表达意味着当 PD-1/PD-L1 的结合被阻断时
Expanding Human T Regulatory Cells with the mTOR-Inhibitor Rapamycin
increasing momentum. However, given the limited amount of circulating FOXP3+ Treg cells, efficient methods for their ex vivo expansion are highly desirable. Rapamycin allows for in vitro expansion of murine and human FOXP3+ Treg cells, which maintain
-amylases of diverse origin. Three major groups of α-amylase have been characterized, based on molecular weight: 60,000, 24,000, and 12,500 Da. The inhibitor forms a complex with amylase. The complex formation can inactivate the amylase and in turn cause
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