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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
- 保质期:
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
- 英文名:
Acetylcysteine; N-Acetyl-L-cysteine;LNAC;NAC
- 库存:
13
- 供应商:
爱必信(上海)生物科技有限公司
- CAS号:
616-91-1
- 规格:
5g/200mg/500mg/100mg
| 规格: | 5g | 产品价格: | ¥700.0 |
|---|---|---|---|
| 规格: | 200mg | 产品价格: | ¥300.0 |
| 规格: | 500mg | 产品价格: | ¥540.0 |
| 规格: | 100mg | 产品价格: | ¥180.0 |
| 公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)!
抑制剂描述: 产品名称:Acetylcysteine 产品别名:见爱必信官网 英文别名:Acetylcysteine 靶点:ROS CAS:616-91-1 纯度:>98% 外观:见爱必信官网 保存方法:Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution. 描述:
Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates.
溶解性:DMSO : 31 mg/mL (190 mM) 体外研究: N-acetylcysteine inhibits activation of c-Jun N-terminal kinase, p38 MAP kinase and redox-sensitive activating protein-1 and nuclear factor kappa B transcription factor activities regulating expression of numerous genes. N-acetylcysteine can also prevent apoptosis and promote cell survival by activating extracellular signal-regulated kinase pathway, a concept useful for treating certain degenerative diseases. N-acetylcysteine directly modifies the activity of several proteins by its reducing activity. N-acetylcysteine prevents apoptotic DNA fragmentation and maintains long-term survival in the absence of other trophic support in serum-deprived PC12 cells. N-acetylcysteine also prevents death of PC12 cells and sympathetic neurons. N-acetylcysteine causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells. N-acetylcysteine activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. N-acetylcysteine protects neuronal cells from death evoked by withdrawal of trophic support. N-acetylcysteine increases nitric oxide (NO) release from protein-bound stores in vascular tissue. N-acetylcysteine pretreatment of PC12 cells interferes with NGF-dependent signaling and neurite outgrowth, and it was suggested that NAC interferes with redox-sensitive steps in the NGF mechanism. 体内研究:N-acetylcysteine improves cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight.
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文献和实验- ROS-activated CXCR2+ neutrophils recruited by CXCL1 delay denervated skeletal muscle atrophy and undergo P53-mediated apoptosisYaoxian Xiang, Junxi Dai, Yao Li, Zongqi You, Junpeng Zhang, Xinying Huang, Shuqi Nie, Yujie Chen, Lei Xu, Fengming Liu, Junjian Jiang, Jianguang Xu
Experimental & Molecular Medicine. 2022 Jul 21 .
影响因子: 12.153
喝咖啡加糖,到底健不健康?中国团队最新研究揭示:喝适量加糖的咖啡,可降低死亡风险
面访谈和身体检查,并提供生物样本。所有参与者均提供了知情同意,将他们的记录与入院、癌症登记和死亡登记相关联。 研究者排除了不符合要求以及中途退出研究的参与者之后,最终共 171,616 名参与者(81.3%)被纳入研究。 研究结果 基线特征 在 171,616 名参与者中,130,132 名(75.8%)是咖啡消费者。最常食用的是不加糖的咖啡(55.4%),其次是加糖的咖啡(14.3%)和加人造甜味剂的咖啡(6.1%)。加糖和人造甜味剂咖啡的消费者平均分别添加了 1.1 茶匙的糖
面访谈和身体检查,并提供生物样本。所有参与者均提供了知情同意,将他们的记录与入院、癌症登记和死亡登记相关联。 研究者排除了不符合要求以及中途退出研究的参与者之后,最终共 171,616 名参与者(81.3%)被纳入研究。 研究结果 基线特征 在 171,616 名参与者中,130,132 名(75.8%)是咖啡消费者。最常食用的是不加糖的咖啡(55.4%),其次是加糖的咖啡(14.3%)和加人造甜味剂的咖啡(6.1%)。加糖和人造甜味剂咖啡的消费者平均分别添加了 1.1 茶匙的糖
。应用于急、慢性呼吸道炎症而痰多不易咳出的患者。氯化铵吸收可使体液及尿呈酸性,可用于酸化尿液及某些碱血症。溃疡病与肝、肾功能不良者慎用。 乙酰半胱氨酸 乙酰半胱氨酸(acetylcysteine)性质不稳定,能使粘痰中连接粘蛋白肽链的二硫键断裂,变成小分子的肽链,从而降低痰的粘滞性,易于咳出。雾化吸入用于治疗粘稠痰阻塞气道,咳嗽困难者。紧急时气管内滴入,可迅速使痰变稀,便于吸引排痰。有特殊臭味,可引起恶心、呕吐。对呼吸道有刺激性,可致支气管痉挛,加用异丙
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