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- 上海
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- 2025年07月11日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 保质期：
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
- 英文名：
Y 27632
- 库存：
现货
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
146986-50-7
- 规格：
50mg/10mg/5mg
| 规格： | 50mg | 产品价格： | ￥2680.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥860.0 |
| 规格： | 5mg | 产品价格： | ￥620.0 |
| 公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!
抑制剂描述： 产品名称：Y-27632 产品别名：见爱必信官网 英文别名：Y-27632 靶点：ROCK CAS：146986-50-7 纯度：≥98% 外观：见爱必信官网 保存方法：Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. 描述：Y-27632 is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over Others kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK. 溶解性：DMSO : ≥ 32 mg/mL (129.38 mM) 体外研究： Y-27632 inhibits the ROCK family of kinases 100 times more potently than other kinases including protein kinase C, cAMP-dependent kinase and myosin light chain kinase. Y-27632 prolongs the lag time and delays the appearance of BrdU-labeled cells in a concentration-dependent manner, delays of about 1 and 4 h are noticed in the Swiss 3T3 cells treated with 10 and 100 μM Y-27632, respectively. Y-27632 promotes neuronal differentiation of adipose tissue-derived stem cells (ADSCs). Compared to 1.0 and 2.5 µM Y-27632 induced groups, percentages of neuroal-like cells achieved a peak in the 5.0 µM Y-27632 induced group. 体内研究：Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of myoclonic jerks when compare with saline group. Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of clonic convulsions when compare with saline group. Treatment with Dimethylnitrosamine (DMN) causes a significant decrease in rat body and liver weight (DMN-S group) compared with control animals (S-S group). Oral Y27632 (30 mg/kg) essentially prevents this DMN-induced rat body and liver weight loss (DMN-Y group). absin，您身边的科研百宝箱 |
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文献和实验- Caspase 3/ROCK1 pathway mediates high glucose-induced platelet microparticles shedding
Gui Hua Wang,Kun Ling Ma,Yang Zhang,Ze Bo Hu,Liang Liu,Jian Lu,Pei Pei Chen,Chen Chen Lu,Xiong Zhong Ruan,Bi Cheng Liu
Biochemical and Biophysical Research Communications. 2019 Feb 05 ; 2
影响因子： 2.559
Preparation of Carboxypeptidase Y and Its Properties
while high efficiency habit in the scientific research. 【Requirement】 1. Use bread yeast as the original material to extract and condense carboxypeptidase Y, assay its biochemical properties. 2. Through gathering relevant published papers
Krogh 方程式进一步加以论证：x=k[1/(1-y)] 1/n 。假定X=加入的新鲜血清量，y=溶血的百分率，以小数表示，V=斜率，k=常数，转变成对数，上述公式就变成：logx=logk+1/n log[y/(1-y)]，当以50%溶血作为终点时，y/(1-y)=0.5/(1-0.5)=1，代入上述公式，log x=log k+1/n log1，由于-log1=0，log x=log k，x=k，也即表示补体的50%溶血单位k就是加入的新鲜血清量。
Because of their unique transmission properties and male specificity, markers located on the nonrecombining region of the Y chromosome (NRY) have become an important tool in forensic investigation. In the past few years, more than 50
