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- 爱必信(absin)
- abs158256
- 上海
- 2025年07月11日
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- 详细信息
- 技术资料
- 抗体名：
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- 抗体英文名：
,LMNA; LMN1; Prelamin-A/C
- 靶点：
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- 浓度：
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- 应用范围：
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- 宿主：
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- 适应物种：
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- 保质期：
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- 抗原来源：
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- 目录编号：
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- 级别：
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- 库存：
99
- 供应商：
爱必信(上海)生物科技有限公司
- 标记物：
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- 克隆性：
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- 保存条件：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
- 形态：
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- 亚型：
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- 免疫原：
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- 规格：
100ul
| 概述 | |
| 别名 | LMNA; LMN1; Prelamin-A/C |
| 宿主 | Mouse |
| 反应种属 | Human,Mouse,Rat |
| 应用 | WB: 1/500-1/1000, IF: 1/50-1/200 |
| 分子量 | Detects a band of approximately 63,74 kD(Predicted molecular weight: 74 kD) Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
| 免疫原 | Purified recombinant human LMNA protein fragments expressed in E.coli. |
| 性能 | |
| 形式 | Monoclonal Antibody |
| 纯化方法 | Affinity Purified |
| 克隆号 | 5D12 |
| 同种型 | IgG1 |
| 储存/保存方法 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 存储溶液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| 修饰 | Unmodified |
| 靶标 | |
| 背景说明 | Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence. |
| UniProt | P02545 |
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Lamin A/C (5D12) Mouse mAb,
￥2300
