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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
BTK抗体
- 抗体英文名：
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- 目录编号：
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- 级别：
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- 库存：
现货
- 供应商：
爱必信(上海)生物科技有限公司
- 标记物：
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- 克隆性：
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- 保存条件：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
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- 规格：
100ug/50ug
| 规格： | 100ug | 产品价格： | ￥2300.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥1500.0 |
| 公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!
抗体描述： 产品名称：Rabbit anti-BTK Polyclonal Antibody 产品别名：BTK抗体 宿主：Rabbit 反应种属：Human;Mouse;Rat 克隆性：Polyclonal Antibody 保存方法：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles 产品描述：Bruton's tyrosine kinase (Btk) is a member of the Btk/Tec family of cytoplasmic tyrosine kinases. Like other Btk family members, it contains a pleckstrin homology (PH) domain and Src homology SH3 and SH2 domains. Btk plays an important role in B cell development (1,2). Activation of B cells by various ligands is accompanied by Btk membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate (3-5). The membrane-localized Btk is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinases, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation (6,7). The activation of Btk is negatively regulated by PKCβ through phosphorylation of Btk at Ser180, which results in reduced membrane recruitment, transphosphorylation, and subsequent activation (8). The PKC inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal Btk activity (8). 用途范围： WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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文献和实验- Discovery of 4-aminoquinoline-3-carboxamide derivatives as potent reversible Bruton's tyrosine kinase inhibitors for the treatment of rheumatoid arthritisXia YaoXia, Xiuyun Sun, Shuyu Jin, Ling Yang, Hongjiang Xu, Yu Rao
J. Med. Chem.. 2019 Jul 01 .
影响因子： 6.84
- A chemical approach for global protein knockdown from mice to non-human primates Xiuyun Sun,Jun Wang,Xia Yao,Wen Zheng,Yang Mao,Tianlong Lan,Liguo Wang,Yonghui Sun,Xinyi Zhang,Qiuye Zhao,Jianguo Zhao,Rui-Ping Xiao,Xiuqin Zhang,Guangju Ji,Yu Rao
Cell Discov. 2019 Feb 05 .
影响因子： 4.462
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