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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
CXCL12抗体
- 抗体英文名：
Stromal cell-derived factor 1, SDF-1, hSDF-1, C-X-C motif chemokine 12, Intercrine reduced in hepatomas, IRH, hIRH, Pre-B cell growth-stimulating factor, PBSF, SDF-1-beta(3-72), SDF-1-alpha(3-67), CXCL12, SDF1, SDF1A, SDF1B,CXCL12,SDF1, SDF1A, SDF1B
- 靶点：
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- 浓度：
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- 应用范围：
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- 宿主：
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- 适应物种：
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- 保质期：
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- 抗原来源：
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- 目录编号：
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- 级别：
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- 库存：
现货
- 供应商：
爱必信(上海)生物科技有限公司
- 标记物：
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- 克隆性：
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- 保存条件：
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
- 形态：
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- 亚型：
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- 免疫原：
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- 规格：
50ul
| 描述 | Purified Rabbit Polyclonal Antibody (Pab) |
| 别名 | CXCL12抗体;Stromal cell-derived factor 1, SDF-1, hSDF-1, C-X-C motif chemokine 12, Intercrine reduced in hepatomas, IRH, hIRH, Pre-B cell growth-stimulating factor, PBSF, SDF-1-beta(3-72), SDF-1-alpha(3-67), CXCL12, SDF1, SDF1A, SDF1B,CXCL12,SDF1, SDF1A, SDF1B |
| 宿主 | Rabbit |
| 特异性 | This CXCL12 antibody is generated from a rabbit immunized with a recombinant protein. |
| 反应种属 | Human;Mouse |
| 应用 | WB~~1:2000 |
| 分子量 | Predicted molecular weight: 11kD Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
| 类型 | Polyclonal Antibody |
| 同种型 | Rabbit Ig |
| 储存/保存方法 | Maintain refrigerated at 2-8°C for up to 2 weeks. For long time storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| 研究领域 | Cardiovascular;Immunology;Microbiology;Stem Cells |
| 背景说明 | Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1- alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3- 67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T- cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. |
| 细胞定位 | Secreted. |
| UniProt | P48061 |
| 参考文献 | Shirozu M.,et al.Genomics 28:495-500(1995). Yu L.,et al.Gene 374:174-179(2006). Spotila L.D.,et al.Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases. Begum N.A.,et al.Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases. Callebaut C.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. |
All lanes : Anti-CXCL12 Antibody at 1:2000 dilution Lane 1: human heart lysates Lane 2: mouse kidney lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 11 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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文献和实验- Rapamycin pretreatment rescues the bone marrow AML cell elimination capacity of CAR-T cellsZhigang Nian, Xiaohu Zheng, Yingchao Dou, Xianghui Du, Li Zhou, Binqing Fu, Rui Sun, Zhigang Tian，Haiming Wei
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影响因子： 12.531
在免疫反应方面，基于抗原的刺激在体内形成、并与抗原作特异性结合的蛋白质之总称。其化学实质是免疫球蛋白。抗体，按照抗原抗体反应的类型可分别称为沉淀素、凝集素、溶血素、溶菌素、抗毒素、中和抗体等，但这些并不等于有相应的不同抗体存在，一般多只表明抗体反应的多样性而已。抗体在血清中含量最多（体液抗体=humoral antibody）；含有某特定抗体的血清称为抗血或免疫血清。
机体在抗原物质刺激下，由B细胞分化成的浆细胞所产生的、可与相应抗原发生特异性结合反应的免疫球蛋白。因为最初有人用电泳证明血清中抗体活性在γ球蛋白部分，故曾把抗体统称为两种（γ）球蛋白。后来证明，抗体并不都在γ区；而且位于γ区的球蛋白，也不一定都具有抗体活性。1964年，世界卫生组织举行专门会议，将具有抗体活性以及与抗体相关的球蛋白统称为免疫球蛋白（Ig）。如骨髓瘤蛋白，巨球蛋白血症、冷球蛋白血症等患者血清中存在的异常免疫球蛋白以及“正常人”天然存在的免疫
指仅对一种抗原决定基的纯粹的抗体。这类抗体不可能通过将抗原 胞的 Hybridoma，在试管内制成了纯粹的单克隆抗体。用某种抗原使动物产生免疫感应，对应于抗原之不同部分可制成各种不同的抗体复合体。然而，因为一个产生抗体的细胞，只能产生一种抗体，所以骨髓肿瘤细胞与产生抗体细胞间的细胞杂种，可形成边产生抗体边增殖的 hybridoma，将每个杂种细胞进行克隆（无性繁殖系）培养，则一个克隆的细胞群只由单种类产生同一抗体的细胞所组成，这样得到的就是单克隆抗体。此抗体在测定
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