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- 爱必信(absin)
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- 上海
- 2025年07月12日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
8
- 供应商：
爱必信(上海)生物科技有限公司
- 肿瘤类型：
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- 细胞类型：
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- 品系：
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- 组织来源：
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- 相关疾病：
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- 物种来源：
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- 免疫类型：
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- 细胞形态：
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- 是否是肿瘤细胞：
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- 器官来源：
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- 运输方式：
store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
- 年限：
store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
- 生长状态：
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- 英文名：
Belnacasan；VX-765；VX 765
- 规格：
100mg/50mg/10mg
| 规格： | 100mg | 产品价格： | ￥5368.0 |
|---|---|---|---|
| 规格： | 50mg | 产品价格： | ￥3574.0 |
| 规格： | 10mg | 产品价格： | ￥1128.0 |
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产品描述： 产品名称：VX765 中文别名: Belnacasan；VX-765；VX 765 靶点: Caspase-4；Caspase-1 CAS号: 273404-37-8 描述: Belnacasan (VX-765)是一种有效的选择性caspase-1抑制剂，无细胞试验中Ki为0.8 nM。 分子式: C24H33ClN4O6 外观: White powder In vitro(体外研究): VX-765 is an orally absorbed prodrug of VRT-043198, which exhibits potent inhibition against ICE/caspase-1 and caspase-4 with Ki of 0.8 nM and less than 0.6 nM, respectively. And VRT-043198 also inhibits IL-1β release from both PBMCs and whole blood with IC50 of 0.67 μM and 1.9 μM, respectively. 分子量: 509.0 In vivo(体内研究): In collagen-induced arthritis mouse model, VX-765 (200 mg/kg) inhibits LPS-induced IL-1β production by about 60%, and results in a dose-dependent, statistically significant reduction in the inflammation scores and effective protection from joint changes. In vivo, VX-765 blocks kindling epileptogenesis in rats by preventing IL-1β increase in forebrain astrocytes without significant effect on afterdischarge duration. In the mouse model of acute seizures, VX-765 (50 mg/kg-200 mg/kg) produces the anticonvulsant effect by delaying the time to onset of the first seizure and decreasing the number of seizures as well as their total duration by average 50% and 64%. In adult rats with genetic absence epilepsy (GAERS), VX-765, after the 3rd drug injection, significantly reduces the cumulative duration and number of spike-and-wave discharges (SWDs) by 55% on average by selectively blocking IL-1β biosynthesis. 纯度: ＞98% 储存/保存方法: store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 可溶性/溶解性: DMSO ：100 mg/mL warmed (196.46 mM)
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文献和实验- PORIMIN: The key to (+)-Usnic acid-induced liver toxicity and oncotic cell death in normal human L02 liver cellsSukfan P.Kwong, Zhenlin Huang, Lili Ji, Changhong Wang
Journal of Ethnopharmacology. 2021 Apr 24 .
影响因子： 4.36
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