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- Elabscience
- E-AB-51043
- 武汉
- 2026年09月20日
- IHC-p
- Mouse
- Human;Mouse;Rat
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- 文献和实验
- 技术资料
- 抗体名：
Phospho-SMAD3 (Ser425) Monoclonal Antibody_货号:E-AB-51043_修饰性抗体
- 抗体英文名：
Phospho-SMAD3 (Ser425) Monoclonal Antibody
- 靶点：
Phospho-SMAD3 (Ser425)
- 浓度：
5 μL/Test
- 应用范围：
IHC-p
- 宿主：
Mouse
- 适应物种：
Human;Mouse;Rat
- 保质期：
12个月
- 级别：
科研
- 库存：
99
- 供应商：
武汉伊莱瑞特生物科技股份有限公司
- 标记物：
Unconjugated
- 克隆性：
Monoclonal
- 保存条件：
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
- 形态：
液体
- 亚型：
IgG
- 规格：
120μL/60μL/20μL
| 规格： | 120μL | 产品价格： | ￥2415.0 |
|---|---|---|---|
| 规格： | 60μL | 产品价格： | ￥1510.0 |
| 规格： | 20μL | 产品价格： | ￥630.0 |
货号：E-AB-51043
| Verified Samples |
Verified Samples in IHC:Human skin
|
| Dilution |
IHC 1:50-300
|
| Clonality |
Monoclonal
|
| Isotype |
IgG
|
| Immunogen |
Synthetic Peptide of Phospho-Smad3 (Ser425)
|
| Abbre |
Phospho-SMAD3 (Ser425)
|
| Synonyms |
DKFZP586N0721;DKFZp686J10186;hMAD 3;hMAD-3;hSMAD3;HSPC193;HST17436;JV15 2;JV15-2;JV152;LDS1C;LDS3;MAD (mothers against decapentaplegic Drosophila) homolog 3;MAD homolog 3;Mad homolog JV15 2;Mad protein homolog;MAD;mothers against decapentaplegic homolog 3;Mad3;MADH 3;MADH3;MGC60396;Mothers against decapentaplegic homolog 3;Mothers against DPP homolog 3;SMA and MAD related protein 3;SMAD 3;SMAD;SMAD family member 3;SMAD;mothers against DPP homolog 3;Smad3;SMAD3抗体
|
| Swissprot |
P84022
|
| Cellular Localization |
Cytoplasm. Nucleus. Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:15799969). Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15601644). MAPK-mediated phosphorylation appears to have no effect on nuclear import (PubMed:19218245). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236).
|
| Concentration |
1 mg/mL
|
| Storage |
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
|
| Buffer |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
|
| Purification Method |
Protein A purification
|
| Research Areas |
Cancer; Epigenetics and Nuclear Signaling; Metabolism; Signal Transduction; Stem Cells
|
| Clone No. |
Clone:4C5
|
| Conjugation |
Unconjugated
|
| Background |
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
|
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文献和实验Sonodynamic Therapy Inhibits Fibrogenesis in Rat Cardiac Fibroblasts Induced by TGF-β1
IF:4.652
Journal:CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
DOI:10.1159/000452571
, each time with 1 ug/ml LPS and collect sup after 2 days each. Pool the sups, filter and use as recommended. (Could be aliquoted and stored at -20C.) Preparation of Media: for P3X63-Ag8.653: IMDM complete to 425 ml of IMDM add:
Using Phospho‐Motif Antibodies to Determine Kinase Substrates
comprising both the phosphorylated residue and the surrounding residues that determine kinase specificity, with degenerate residues taking up the remaining positions. Currently, several categories of phospho?motif antibody are commercially available
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对照，2道为1:1000倍稀释我们先看一下EarthOx的单克隆GFP抗体——Anti-GFP Tag Monoclonal Antibody [GF28R]（货号#E022030），其免疫原是KLH偶联的水母GFP蛋白的N末端多肽，由于EGFP、YFP、EYFP、CFP得N末端序列与GFP几乎完全一致，因此从免疫原上来说，GFP与EGFP、YFP、EYFP、CFP没有区别。更重要的是，EarthOx对于该单克隆抗体还进行了明确的验证试验，试验也表明该Anti-GFP Tag Monoclonal
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