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Phospho-SMAD3 (Ser425) Monoclonal Antibody_货号:E-AB-51043_修饰性抗体
Phospho-SMAD3 (Ser425) Monoclonal Antibody
IHC-p
Mouse
Human;Mouse;Rat
12个月
E-AB-51043
科研级别
999
武汉伊莱瑞特生物科技股份有限公司
Unconjugated
Monoclonal
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
液体
IgG
120μL/60μL/20μL
规格: | 120μL | 产品价格: | ¥2415.0 |
---|---|---|---|
规格: | 60μL | 产品价格: | ¥1510.0 |
规格: | 20μL | 产品价格: | ¥630.0 |
Verified Samples |
Verified Samples in IHC:Human skin
|
Dilution |
IHC 1:50-300
|
Clonality |
Monoclonal
|
Isotype |
IgG
|
Immunogen |
Synthetic Peptide of Phospho-Smad3 (Ser425)
|
Abbre |
Phospho-SMAD3 (Ser425)
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Synonyms |
DKFZP586N0721;DKFZp686J10186;hMAD 3;hMAD-3;hSMAD3;HSPC193;HST17436;JV15 2;JV15-2;JV152;LDS1C;LDS3;MAD (mothers against decapentaplegic Drosophila) homolog 3;MAD homolog 3;Mad homolog JV15 2;Mad protein homolog;MAD;mothers against decapentaplegic homolog 3;Mad3;MADH 3;MADH3;MGC60396;Mothers against decapentaplegic homolog 3;Mothers against DPP homolog 3;SMA and MAD related protein 3;SMAD 3;SMAD;SMAD family member 3;SMAD;mothers against DPP homolog 3;Smad3;SMAD3抗体
|
Swissprot |
P84022
|
Cellular Localization |
Cytoplasm. Nucleus. Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:15799969). Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15601644). MAPK-mediated phosphorylation appears to have no effect on nuclear import (PubMed:19218245). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236).
|
Concentration |
1 mg/mL
|
Storage |
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
|
Buffer |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
|
Purification Method |
Protein A purification
|
Research Areas |
Cancer; Epigenetics and Nuclear Signaling; Metabolism; Signal Transduction; Stem Cells
|
Clone No. |
Clone:4C5
|
Conjugation |
Unconjugated
|
Background |
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
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