- ￥630 - 2415
- Elabscience
- 湖北武汉
- E-AB-21338
- 2025年07月14日
- IHC-p
- Mouse
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 亚型：
IgG
- 形态：
液体
- 保存条件：
在-20℃下储存有效期为12个月。 避免冻融循环。
- 克隆性：
Monoclonal
- 标记物：
Unconjugated
- 适应物种：
Human
- 保质期：
12个月
- 目录编号：
E-AB-21338
- 级别：
科研级别
- 库存：
999
- 供应商：
武汉伊莱瑞特生物科技股份有限公司
- 宿主：
Mouse
- 应用范围：
IHC-p
- 抗体英文名：
Phospho-MLKL (Ser358) Monoclonal Antibody
- 抗体名：
Phospho-MLKL (Ser358) 单克隆抗体_货号:E-AB-21338_修饰性抗体
- 规格：
120μL/60μL/20μL
| 规格： | 120μL | 产品价格： | ￥2415.0 |
|---|---|---|---|
| 规格： | 60μL | 产品价格： | ￥1510.0 |
| 规格： | 20μL | 产品价格： | ￥630.0 |
Phospho-MLKL (Ser358) 单克隆抗体产品名称：Phospho-MLKL (Ser358) 单克隆抗体， 货号：E-AB-21338
| 已验证样本 | 免疫组织化学（IHC）已验证样本:Human colon carcinoma,Human skin |
| 稀释 | IHC 1:100-200 |
| 克隆性 | Monoclonal |
| 同种型 | IgG |
| 免疫原 | Synthetic Peptide of Phospho-MLKL (Ser358) |
| Abbre | Phospho-MLKL (Ser358) |
| 同义词 | 9130019I15Rik;FLJ34389;hMLKL;Mixed lineage kinase domain like;Mixed lineage kinase domain like protein;Mixed lineage kinase domain like pseudokinase;Mixed lineage kinase domain-like protein;Mlkl;MLKL抗体 |
| Swissprot | Q8NB16 |
| 细胞定位 | Cytosol,Plasma Membrane,Other locations:cytoplasm |
| 浓度 | 1 mg/mL |
| 储存方法 | 在-20℃下储存有效期为12个月。 避免冻融循环。 |
| 缓冲 | PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4 |
| 纯化方法 | Protein A purification |
| 研究领域 | Cancer; Signal Transduction |
| Clone No. | Clone:6E3 |
| Conjugation | Unconjugated |
| 产品描述： | This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.MLKL (Mixed Lineage Kinase Domain Like Pseudokinase) is a Protein Coding gene. Among its related pathways are Apoptosis and Autophagy and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. |
Phospho-MLKL (Ser358) 单克隆抗体labscience®拥有先进的单抗，多抗和流式抗体开发技术平台，提供8500+高品质 抗体， 适用于胞内和胞外蛋白的鉴定、定量和定位研究。抗体已在多种应用中得到验证，包含 流式细胞术（Flow Cytometry）、 免疫印迹（WB）、 免疫组化（IHC/ICC）、 免疫（共）沉淀（IP/Co-IP）、 免疫荧光（IF） 等实验。抗体产品涉及多种生命科学研究领域，包括肿瘤、免疫、心血管、细胞生物学、神经科学、表观遗传学等。Elabscience®始终致力于提高抗体的质量和种类，以保障并加快您的研究进程
在-20℃下储存有效期为12个月。 避免冻融循环。Phospho-MLKL (Ser358) 单克隆抗体产品更多产品信息查看欢迎咨询我们和搜索武汉伊莱瑞特Elabscience官网查看。
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文献和实验Using Phospho‐Motif Antibodies to Determine Kinase Substrates
the phosphorylation site; therefore, substrate?directed, phosphorylation?state?sensitive, motif?specific (?phospho?motif?) antibodies represent powerful tools to identify novel kinase substrates and to investigate mechanisms of substrate phosphorylation
), and causes activation of KOR. Agonist-activated KOR becomes a substrate for G protein receptor kinase (GRK), which phosphorylates the Ser369 residue at the C-terminal tail of the receptor in the first step in the β-Arrestin-dependent desensitization cascade
at 10, 25, and 50 μM). At 24 h post-treatment, celllysates were obtained; SDS-PAGE and Western blotting were performed as described in Section 3, Methods. AR-A014418dose-dependent decreases of phospho-β-catenin (Ser33/37) and phospho-glycogen synthase
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