- 询价
- MP Biomedicals
- 0218397125
- 美国
- 2026年04月23日
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- 库存：
9999
- 供应商：
北京智杰方远科技有限公司
- 英文名：
Azoxymethane
- 规格：
询价
Product Description
Azoxymethane (AOM) is a carcinogen that induces O6-methylguanine adducts in DNA leading to G→A transitions.
Application Notes
Induces tumorigenesis in the colon of laboratory animals and is used to study the mechanism or cancer progression and chemoprevention
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Study the mechanism of cancer progression and chemoprevention
Specifications
| SKU | 0218397125 |
| Alternate Names | AOM |
| Application Notes | Induces tumorigenesis in the colon of laboratory animals and is used to study the mechanism or cancer progression and chemoprevention |
| Base Catalog Number | 183971 |
| Biochemical Physiological Actions | Carcinogen that induces O6-methylguanine adducts in DNA leading to G?A transitions. Induces tumorigenesis in the colon of laboratory animals and is used to study the mechanism and of cancer progression and chemoprevention. |
| Boiling Point | 97-99 °C |
| CAS # | 25843-45-2 |
| Density | 0.991 g/mL at 25 °C |
| Flash Point | 24 °C/ 75.2 °F |
| Hazard Statements | H300-H350 |
| Molecular Formula | CH3N=N(←O)CH3 |
| Molecular Weight | 74.08 |
| Pack Size | 25 mg |
| RTECS Number | PA2975000 |
| Safety Symbol | GHS06, GHS08 |
| Storage | Store a -20 °C |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
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文献和实验内消除β-链蛋白后,包括黏膜型基质金属蛋白酶(MTl-MMP)的84项基因表达下调。而在24株结肠癌细胞的22株中MTl-MMP的表达上调。因此，作者推测β-链蛋白的积累是通过影响MTl-MMP的表达而发挥对结肠黏膜的致癌作用的。 Nambiar等在某些结肠癌细胞中用基因芯片分析基因表达谱时发现p53的表达有不同的改变(表达上调、下调和正常)，虽然在有些肿瘤组织中p53的表达水平上调30倍，但似乎并没有发挥生物学效应，也末见其诱导p27基因表达的变化。在用azoxymethane(AOM)诱导的鼠
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