Anifrolumab阿鲁尼单抗阿鲁尼单抗,1326232-

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Anifrolumab

CAS No. : 1326232-46-5

MCE 国际站：Anifrolumab

产品活性：Anifrolumab 是一种 I 型干扰素 (IFN) 受体拮抗剂，是一种人源单克隆抗体。Anifrolumab 能阻断 I 型干扰素的活性，可用于系统性红斑狼疮 (SLE) 的研究。

研究领域：Others

作用靶点：Others

In Vitro: Anifrolumab (67.7 nM; 20 min) induces sustained reduction of surface IFNAR1 and abrogates STAT1 phosphorylation.
Anifrolumab (1 and 10 μg/mL; 6 or 7 d) suppresses differentiation of B cells into plasma cells.
Anifrolumab inhibits type I IFN-induced ISRE signaling, with IC₅₀s ranging from 0.004 to 0.3 nM for the IFN-α subtypes, and 0.03 nM and 0.07 nM for IFN-β and IFN-ω, respectively.
Anifrolumab (67.7 nM) dose-dependently inhibits IFN-α production from pDCs in response to CpG-A or DNA-IC stimulation, inhibiting 87-95% of IFN-α production.

相关产品：Digitonin  |  5-Ph-IAA  |  FLAG peptide  |  Tocofersolan  |  Monocrotaline  |  Lactate sodium  |  TCEP hydrochloride  |  3X FLAG peptide  |  DPPH  |  Pertussis Toxin  |  Pronase E (Activity ≥ 7000 U/g)  |  O-Propargyl-Puromycin  |  NMDI14  |  Phytohemagglutinin  |  MYLS22  |  Hyaluronidase  |  Biotinyl tyramide  |  Kifunensine  |  Human IgG1 kappa, Isotype Control  |  4-Azido-L-phenylalanine  |  6-Aminonicotinamide  |  Ammonium tetrathiomolybdate(VI)  |  OVA Peptide(257-264) TFA  |  Alkyne-phenol  |  Lauryl maltose neopentyl glycol  |  SHIN1  |  CHAPS  |  Cytosporone B

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds