- ￥1170 - 9180
- TargetMol
- 美国
- T38153
- 2025年07月14日
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- 文献和实验
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
NF-κB Inhibitor (trifluoroacetate salt)
- 库存：
10
- 供应商：
TargetMol
- 规格：
5 mg/500 μg/1 mg
| 规格： | 5 mg | 产品价格： | ￥9180.0 |
|---|---|---|---|
| 规格： | 500 μg | 产品价格： | ￥1170.0 |
| 规格： | 1 mg | 产品价格： | ￥2240.0 |
Product Introduction
Bioactivity
英文名:NF-κB Inhibitor (trifluoroacetate salt)
描述:NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.1It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.1In this way, NF-κB inhibitor blocks gene expression that is regulated by NF-κB.2,3This peptide is commonly used to evaluate the role of NF-κB signaling in cellular responses.4,5
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文献和实验Activation of Nuclear Factor-B (NF-B) in Mononuclear Cells (MNC)
in a rapid fashion (2 ). NF-κB interacts with its inhibitor protein IκB and activation of NF-κB causes it to move into the nucleus and this is controlled by the phosphorylation and subsequent degredation of IκB (3 ,4 ). The activated form of NF-κB
The nuclear factor-kappa B (NFκB) family of transcription factors has emerged as a signaling pathway that figures prominently in a cell’s initial response to a plethora of inflammatory stimuli. Modified lipids, oxidative stress, bacterial
in regulating early response gene programs to injury and infection. Inhibition of NF-κB by expression of a dominant negative signal phosphorylation site mutant of inhibitor-κB, IκBαM, under a tetracycline inducible promoter, established the role of NF-κB
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