- ￥6768
- AntibodySystem
- 62.5 - 4,000 ng/mL
- 45.51 ng/mL
- France
- KDC29905
- 2025年12月21日
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
武汉益普生物科技有限公司
- 检测范围：
62.5 - 4,000 ng/mL
- 检测方法：
Colorimetric
- 样本：
Plasma, Serum
- 灵敏度：
45.51 ng/mL
- 规格：
96T
| 产品名 | Teprotumumab ELISA Kit |
| 货号 | KDC29905 |
| 规格 | 96T |
| 别名 | RO4858696-000, CAS: 1036734-93-6 |
| 应用 | Used for the quantitative determination of Teprotumumab concentration in serum and plasma. |
| 检测方法 | Colorimetric |
| 样本类型 | Plasma, Serum |
| 实验类型 | Quantitative |
| 检测范围 | 62.5 - 4,000 ng/mL |
| 灵敏度 | 45.51 ng/mL |
| 回收率 | 80-120% |
| 精准度 | CV<20% |
| 描述 | PRINCIPLE OF THE ASSAY This assay employs the quantitative competitive enzyme immunoassay technique. Recombinant Human IGF1R has been pre-coated onto a microplate. Standards or samples are premixed with biotin-labeled antibody and then pipetted into the wells. Teprotumumab in the sample competitively binds to the pre-coated protein with biotin-labeled Teprotumumab. After washing away any unbound substances, Streptavidin-HRP is added to the wells. Following a wash to remove any unbound enzyme reagent, a substrate solution is added to the wells and color develops in inversely proportion to the amount of Teprotumumab bound in the initial step. The color development is stopped and the intensity of the color is measured. |
| 背景 | Teprotumumab is a human IgG1 monoclonal antibody directed against the insulin-like growth factor 1 receptor (IGF1R) that is used in the therapy of Graves ophthalmopathy (thyroid eye disease). Graves disease is an autoimmune disease associated with autoantibodies, hyperthyroidism and a distinctive form of eye disease marked by ocular inflammation and proptosis causing eye pain, dryness, redness, and swelling which if severe can cause diplopia (double-vision) and loss of vision. Graves ophthalmopathy is associated with autoantibodies to thyrotropin and hypertrophy of ocular fibroblasts which overexpress the IGF1 receptor. Teprotumumab causes inhibition of IGF1 binding to its receptor and preventing cell activation. IGF1 is a potent modulator of cell growth and inhibitor of programmed cell death, acting via the PI3K-AKT-mTOR pathway. The inhibition of IGF1 signaling decreases fibroblast proliferation and hypertrophy. |
| 稳定性和存储 | When the kit was stored at the recommended temperature for 6 months, the signal intensity decreased by less than 20%. For unopened kits, if you want to prolong the storage time, please store the Standard, Detection A, Detection B and Microplate at - 20℃, the rest reagents should be store at 4℃. |
| 保存方法 | 2-8 ℃ |
| 说明 | For Research Use Only. |
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文献和实验市面上的 ELISA 试剂盒五花八门，质量良莠不齐。如何浪里淘金，选择既符合科研需求，又品质上乘的 ELISA 试剂盒呢? 教你七招，快速搞定 ELISA 试剂盒的选择！ 01 查找待测样本的蛋白浓度 通过检索 SCI 文献、Genecards、Mayocliniclabs 等，获得目标蛋白的表达部位及表达浓度参考值，比较 ELISA 试剂盒中给出的样本测值与参考值是否一致。 02 明确试剂盒的应用种属＆检测的样本类型 不同厂家验证的样本类型不同。除试剂盒特别说明外，一般情况下，不同
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