- ￥1856
- SIGMA
- 美国
- H0165-10mg
- 2025年07月15日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
瓶身
- 保质期：
coa
- 英文名：
SN-38
- 库存：
999
- 供应商：
麦飞生物
- CAS号：
86639-52-3
- 规格：
H0165-10mg
说明
应用
7-Ethyl-10-hydroxycamptothecin has been used:
to inhibit enterovirus 71 (EV71) (H) infection[1]
to screen the chemosensitivity of pancreatic adenocarcinoma cells[2]
as a chemical to study its ability to reverse multidrug resistance (MDR), due to ATP binding cassette (ABC) transporters[3]
生化/生理作用
Active metabolite of irinotecan. Inhibitor of topoisomerase I.. Gene expression analysis of colon cancer cell lines treated with SN-38 showed differential effects: the majority of affected genes were down-regulated (including, most strongly, genes related to receptor and kinase activity, signal transduction, apoptosis, RNA processing, protein metabolism and transport, cell cycle and transcription. Some of the up-regulated genes were involved in apoptosis, transcription, development and differentiation.
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文献和实验Dual roles for splice variants of the glucuronidation pathway as regulators of cellular metabolism.
Mélanie Rouleau et al.
Molecular pharmacology, 85(1), 29-36 (2013-10-22)
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