- ￥608
- SIGMA
- 美国
- 239802-100mg
- 2026年04月20日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
瓶身
- 保质期：
coa
- 英文名：
458-37-7
- 库存：
999
- 供应商：
麦飞生物
- 规格：
239802-100mg
说明
一般描述
A cell permeable antitumor and anti-inflammatory agent that acts as an inhibitor of 5-lipoxygenase (IC50 = 8 µM) and cyclooxygenase (IC50 = 52 µM). Confers significant protection against neurotoxic and genotoxic agents. Also inhibits the induction of nitric oxide synthase in activated macrophages (IC50 = 6 µM). Recently shown to inhibit the EGF receptor intrinsic kinase activity in the human epidermoid carcinoma A431 cells in a dose- and time-dependent manner. Also shown to be a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, inhibiting the acetylation of histones H3 and H4 with an
IC50 of ~25 µM. Does not affect p300/CREB binding protein-associated factor (PCAF).
A cell-permeable and irreversible antitumor and anti-inflammatory agent that acts as an inhibitor of 5-lipoxygenase (IC50 = 8 µM) and cyclooxygenase (IC50 = 52 µM). Confers significant protection against neurotoxic and genotoxic agents. Also inhibits the induction of nitric oxide synthase in activated macrophages (IC50 = 6 µM). Recently shown to inhibit the EGF receptor intrinsic kinase activity in the human epidermoid carcinoma A431 cells in a dose- and time-dependent manner. Also shown to be a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, inhibiting the acetylation of histones H3 and H4 with an IC50 of ~25 µM. Does not affect p300/CREB binding protein-associated factor (PCAF).
生化/生理作用
Cell permeable: yes
Primary Target
5-lipoxygenase
Product does not compete with ATP.
Reversible: no
Target IC50: 8 µM, 52 µM, against 5-lipoxygenase, Cyclooxygenase, respectively; 6 µM inhibiting the induction of nitric oxide synthase in activated macrophages
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
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文献和实验Curcumin inhibits the survival and metastasis of prostate cancer cells via the Notch-1 signaling pathway.
Jingzhe Yang et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 125(2), 134-140 (2017-01-26)
。 本科的砂仁（Amomum villosum Lour.），分布华南至西南，果入药。姜黄属(Curcuma)的姜黄（C. longa L.）分布东南至西南，根茎与块根入药。同属的郁金（C. aromatica Salisb.）、温郁金（C. wenyujin Y. H. Chen et C. Ling）等种的块根均作“郁金”入药。山姜属（Alpinia）的山姜[A. japonica (Thunb.) Miq.]等为常见的药用植物。艳山姜[A. zerumbet (Pers.) Burtt et
[摘要] 目的：筛选超临界CO2萃取姜黄中姜黄素的姜黄素的工艺条件，采用HPLC法测定姜黄素含量。结果取温度55℃，采用无水乙醇作为夹带剂与超临界CO2流萃取5 h，CO2流量3.5 L/min。结论：超临界CO2萃取姜，切实可行。 [关键词] 姜黄；姜黄素；超临界CO2萃取；HPLC 姜黄始载于《唐本草》，为姜科Zingiberaceae植物姜黄Curcuma longa L．的干燥根茎，其性燥而温，味苦而辛，具有行气止痛、通经破血、祛风疗痹等功效，是临床上常用的中药
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