Flt-3 Ligand, also known as FL, is an αhelical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. Mature human Flt-3 Ligand consists of a 158 amino acid (aa) extracellular domain (ECD) with a cytokinelike domain and a juxtamembrane tether region, a 21 aa transmembrane segment, and a 30 aa cytoplasmic tail. Flt-3 Ligand is expressed as a noncovalentlylinked dimer by T cells and bone marrow and thymic fibroblasts. Animal studies show Flt-3 Ligand to reduce the severity of experimentally induced allergic inflammation. 仅供实验室使用。