- ￥3300
- Leading Biology
- AMM15647VCF
- 美国
- 2025年07月10日
- WB 1:200 - 1:1000
- Mouse
- Human
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![KIAA1970 (EARS2) Mouse Monoclonal Antibody [Clone ID: LBI2B1]](https://img1.dxycdn.com/2022/0707/344/1496323853485278553-14.jpg!wh200)
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- 详细信息
- 文献和实验
- 技术资料
- 靶点：
MSR1
- 应用范围：
WB 1:200 - 1:1000
- 宿主：
Mouse
- 适应物种：
Human
- 保质期：
1-2年
- 供应商：
安诺伦（北京）生物科技有限公司
- 标记物：
Unconjugated
- 克隆性：
Monoclonal Antibody
- 保存条件：
Stable for 1 year at -20°C from date of shipment. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
- 形态：
Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
- 亚型：
IgG1
- 免疫原：
Human recombinant protein fragment corresponding to amino acids 197-451 of human MSR1(NP_619730) produced in E.coli.
- 规格：
100 ug
产品概述：Carrier-free (BSA/glycerol-free) MSR1 mouse monoclonal antibody, clone LBI1F10
总结：This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
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文献和实验---------------------------------------------------------------------------- Innate immunity The innate immune response is the first line of defence against pathogens. Phagocyte recognition and uptake of pathogens involves pattern-recognition molecules such as the macrophage mannose receptor
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