GSK3987,264206-85-1

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GSK3987

CAS No. : 264206-85-1

MCE 国际站：GSK3987

产品活性：GSK3987 是一种广泛的 LXRα/β 激动剂，EC₅₀ 分别为 50 nM 和 40 nM。GSK3987 增加 ABCA1 和 SREBP-1c 蛋白的表达。GSK3987 诱导细胞胆固醇流出和甘油三酯的积累。

研究领域：Metabolic Enzyme/Protease  |  Vitamin D Related/Nuclear Receptor

作用靶点：LXR

In Vitro: GSK3987 (compound 4) shows activity with EC₅₀s of 0.08 μM, 50 nM, 40 nM for ABCA1, LXRα-SRC1, LXRβ-SRC1, respectively.
?GSK3987 (30, 100, 300, 1000 nM) increases the expression of ABCA1 and induces cellular cholesterol efflux to apoA1 particles in a dose-dependent manner in primary human macrophages.
?GSK3987 (6-1500 nM) increases the expression of SREBP-1c and induces triglyceride accumulation in human hepatoma (HepG2) cells in a dose-dependent manner.

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