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- 详细信息
- 文献和实验
- 技术资料
- 库存：
大量
- 英文名：
Alexa Fluor® 647 anti-human CD64 Antibody
- CAS号：
Alexa Fluor® 647 anti-human CD64 Antibody
- 保质期：
详见说明
- 供应商：
齐源生物
- 保存条件：
2-8℃
- 规格：
100 tests
Other Names：FcγRI, FcR I
Isotype：Mouse IgG1, κ
Description：
CD64 is a 72 kD single chain type I glycoprotein also known as FcγRI and FcR I. CD64 is a member of the immunoglobulin superfamily and is expressed on monocytes/macrophages, dendritic cells, and activated granulocytes. The expression can be upregulated by IFN-γ stimulation. CD64 binds IgG immune complex. It plays a role in antigen capture, phagocytosis of IgG/antigen complexes, and antibody-dependent cellular cytotoxicity (ADCC).
Isotype Control：Alexa Fluor® 647 Mouse IgG1, κ Isotype Ctrl (FC)
Reactivity：Human, Baboon, Capuchin Monkey, Chimpanzee, Cynomolgus, Rhesus, Squirrel Monkey
Antibody Type：Monoclonal
Host Species：Mouse
Immunogen：Human rheumatoid synovial fluid cells and fibronectin-purified monocytes.
Formulation：Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
Preparation：The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
Concentration：Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling：The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application：FC - Quality tested
Recommended Usage：Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633nm / 635nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
Excitation Laser：Red Laser (633 nm)
Application Notes：Clone 10.1 recognizes the EC3 epitope of CD64. While both contain the EC3 domain, in-house testing suggests that clone 10.1 preferentially binds to CD64A (FcγRIA), but not CD64B (FcγRIB). Additional reported applications (for the relevant formats) include: blocking of human IgG3 and murine IgG2a binding to FcγRI2,5,6,11 and immunohistochemical staining of acetone-fixed frozen tissue sections12.
Application References：
1.McMichael A, et al. Eds. 1987. Leucocyte Typing III. Oxford University Press. New York.
2.Schlossman S, et al. Eds. 1995. Leucocyte Typing V. Oxford University Press. New York. p. 874.
3.Kishimoto T, et al. Eds. 1997. Leucocyte Typing VI. Garland Publishing Inc. London.
4.Holl V, et al. 2004. J. Immunol. 173:6274.
5.Hober D, et al. 2002. J. Gen. Virol. 83:2169.
6.Cho HJ, et al. 2007. Physiol Genomics 149:60.
7.van Tits L, et al. 2005. Arterioscler Thromb Vasc Biol. 25:717. PubMed
8.Bruhns P, et al. 2008. Blood 113:3716. PubMed
9.Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
10.Carter DL, et al. 1999. Cytometry 37:41. (FC)
11.Dougherty GJ, et al. 1987. Eur. J. Immunol. 17:1453.
12.Blom AB, et al. 2003. Arthritis Rheum. 48(4):1002-14. (IHC)
Product Citations：
1.Khare P, et al. 2017. J Autoimmun. 10.1016/j.jaut.2017.09.002. PubMed
2.Poel C, et al. 2010. Blood. 116:5327. PubMed
Structure：Ig superfamily, type I glycoprotein, 72 kD
Distribution：Monocytes, macrophages, dendritic cells, activated granulocytes
Function：Phagocytosis, ADCC
Ligand/Receptor：IgG receptor
Cell Type：Dendritic cells, Granulocytes, Macrophages, Monocytes
Biology Area：Immunology, Innate Immunity
Molecular Family：CD Molecules, Fc Receptors
Antigen References：
1. Hulett M, et al. 1994. Adv. Immunol. 57:1.
2. van de Winkel J, et al. 1993. Immunol. Today 14:215.
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文献和实验常用抗体标记荧光染料的选择 随着免疫荧光技术的不断发展，荧光染料及其标记的抗体偶联物也被广泛的应用于生物学实验中。目前，市场上抗体及蛋白标记的荧光染料主要有CFTM系列(BIOTIUM, USA); Alexa Fluor®系列 (Life technology, USA); DyLight系列;Cy系列; IR Dye系列等等。使用最多的为AlexaFluor®系列和CFTM系列。CFTM系列染料的核心对比AlexaFluor®系列具有以下几点优势：1. 新型罗丹明核心罗丹明染料以优异
技术原理与方法｜超级色差校正物镜 PLAPON60XOSC 在脑组织四重免疫荧光分析中的应用
种类型的荧光抗体在单个标本中准确展示荧光标记分子的共定位情况。 PLAPON60XOSC 和 UPLSAPO60XO 的性能比较 2. 超级色差校正物镜的应用-脑组织的四重免疫荧光 图 1. 脑组织的四重免疫荧光。 VIAAT 染色（Alexa Fluor405，蓝色）；CB1 染色（Alexa Fluor488，绿色）；VGluT3 染色（Cy3，红色）；DGLα染色（Alexa Fluor647，白色）。 大麻素合成酶 DGLα（白色）和大麻素受体 CB1（绿色）聚集在小鼠
红外荧光染料。 以花青素为基础的远红外荧光染料CF 647 比Cy 5、Alexa Fluor 647 明亮。 CF 660、Alexa Fluor® 660, Allophycocyanin (APC)等介于远红外近红外之间的荧光染料。 6、近红外（680-790nm处激发） CF 680R/ 680、Alexa Fluor 680, Cy 5.5, IR Dye 680等近红外荧光染料。 CF680 是高水溶性的以花青素为基础的染料，分子量大约为3000。该染料标记抗体极佳，发出
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