Anti-Mouse CD105/Endoglin|Anti

关键词：Anti-Mouse CD105/Endoglin，Anti-Mouse CD105/Endoglin，Anti-Mouse CD105/Endoglin,Anti-Mouse CD105/Endoglin,ReliaTech

产品名称：Anti-Mouse CD105/Endoglin-Anti-Mouse CD105/Endoglin

产品货号：103-PA60AG

产品规格：50ug

背景资料：Endoglin, also known as CD105, is a Type I integral membrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Two splice variants of human Endoglin, the S-Endoglin and L-Endoglin that differ in the length of their cytoplasmic tails have been identified. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, bone marrow pro-erythroblasts, and leukemic cells of lymphoid and myeloid lineages. Human and mouse Endoglin share approximately 70% and 97 % amino acid sequence identity in their extracellular and intracellular domains, respectively. It has clearly been shown that CD105/Endoglin is required for angiogenesis and it plays a key role in heart development. Mutations in human Endoglin or ALK-1 (another type I serine/threonine receptor) lead to the vascular disorder hereditary hemorrhagic telangiectasia (HHT). Mice heterozygous for Endoglin have been developed as disease models for HHT. Endoglin has been shown to be a powerful marker of neovascularization. It is also useful as a functional marker that defines long-term repopulating hematopoietic stem cells.

保存建议：Anti-Mouse CD105/Endoglin-Anti-Mouse CD105/Endoglin该Anti-Mouse CD105/Endoglin的详细信息查看ReliaTech提供的产品说明。

产品描述：Rabbit

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