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- YLKBIO
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
优利科（上海）生命科学有限公司
- 库存：
100
- 靶点：
详询
- 级别：
科研
- 目录编号：
/
- 克隆性：
多克隆
- 抗原来源：
详见说明书
- 保质期：
1年
- 抗体英文名：
Anti-IRAK4
- 抗体名：
IRAK4抗体
- 标记物：
详询
- 宿主：
兔
- 适应物种：
/
- 免疫原：
见产品详情
- 亚型：
IgG
- 形态：
冻干或液体
- 应用范围：
见产品详情
- 保存条件：
-20℃
- 浓度：
1mg/ml
- 规格：
详询
| 英文名称 Anti-IRAK4 |
| 中文名称 白介素-1受体相关激酶4抗体 |
| 别 名 IL-1 Receptor-associated Kinase 4; 8430405M07Rik; 9330209D03Rik; IPD1; IRAK4; NY-REN-64; REN64; INTERLEUKIN RECEPTOR-ASSOCIATED KINASE 4. |
| 浓 度 1mg/1ml |
| 规 格 0.2ml/200μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep |
| 产品类型 一抗 |
研究领域 细胞生物 免疫学 激酶和磷酸酶  |
| 蛋白分子量 predicted molecular weight: 51kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthetic peptide derived from human IRAK4 |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
| （石蜡切片需做抗原修复） |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
| 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.  |
| 产品介绍 Interleukin 1 (IL1) and lipopolysaccharide (LPS) induces cellular responses through IL1 receptor (IL1R) and Toll like receptors (TLR). IL1R associated kinases (IRAK, IRAK2, and IRAKM) regulate the activation of NF-kB and MAP kinase (MAPK) by IL1R/TLR. A novel member in the IRAK/Pelle family was recently identified and designated IRAK4. Overexpression of IRAK4 activates NF-kB and MAPK pathways. IRAK4 interacts with and phosphorylates IRAK1. IRAK4 deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL1R/TLR mediated inflammatory responses and in innate immunity. |
| Function : Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. |
| Subunit : Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome. Once phosphorylated, IRAK4 dissociates from the receptor complex and then associates with the TNF receptor-associated factor 6 (TRAF6), IRAK1, and PELI1; this intermediate complex is required for subsequent NF-kappa-B activation. Interacts with IL1RL1. |
| Subcellular Location : Cytoplasm. |
| Post-translational modifications : Phosphorylated. |
| DISEASE : Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) [MIM:610799]. Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD. |
| Defects in IRAK4 are the cause of IRAK4 deficiency (IRAK4D) [MIM:607676]. IRAK4 deficiency causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children. |
| Similarity : Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. |
| Contains 1 death domain. |
Contains 1 protein kinase domain. |
| Anti-HYTAg/HBV（Mouse Anti-Human Hepatitis B Surface Antigen Monoclonal antibody） 鼠抗人乙型肝炎表面抗原抗体 |
| Anti-HBV/pre S1/S2 protein 抗乙肝病毒pre S1/乙肝病毒pre S2抗体 |
| Anti-β-HCG (anti-Human Chorionic Gonadotropin (hCG) beta , for conjugation and detection) 鼠抗人β亚基人绒毛膜促性腺激素单抗 |
| Anti-HCCR-1(BRI3 binding protein) 人宫颈癌基因/bri3结合蛋白抗体 |
| Anti-α -HCG(anti-Human Chorionic Gonadotropin (hCG) α ） 鼠抗人α 亚基人绒毛膜促性腺激素(α -HCG)单抗 |
| Anti-HCV-Core 丙型肝炎病毒-C区抗体 |
| Anti-HCV-HCBP1/ACY-3(Hepatitis C virus core-binding protein 1) 丙型肝炎病毒核心蛋白结合蛋白-1抗体 |
| Anti-HCV-NS1 丙型肝炎病毒-NS1抗体 |
| Anti-HCV-NS3 丙型肝炎病毒-NS3抗体 |
| Anti-HCV-NS4a 丙型肝炎病毒-NS4a抗体 |
| Anti-HDL-R（High Density Lipoprotein Receptor） 高密度脂蛋白受体抗体 |
| Anti-Heamachrome 血红素抗体 |
| Anti-HEV 戊型肝炎病毒抗体 |
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白介素-1受体相关激酶4抗体
￥1680
