- ￥1280 - 1980
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
优利科（上海）生命科学有限公司
- 库存：
96
- 靶点：
详询
- 级别：
科研
- 目录编号：
/
- 克隆性：
多克隆
- 抗原来源：
详见说明书
- 保质期：
1年
- 抗体英文名：
Anti-IGFBP1
- 抗体名：
IGFBP1抗体
- 标记物：
详询
- 宿主：
兔
- 适应物种：
/
- 免疫原：
见产品详情
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
见产品详情
- 保存条件：
-20℃
- 浓度：
1mg/ml
- 规格：
详询
| 英文名称 Anti-IGFBP1 |
| 中文名称 胰岛素样生长因子结合蛋白1抗体 |
| 别 名 Insulin-like Growth Factor Binding Protein 1; IGFBP-1; AFBP; Alpha pregnancy associated endometrial globulin; Amniotic fluid binding protein; Binding protein 25; Binding protein 26; Binding protein 28; Growth hormone independent binding protein; hIGFBP 1; hIGFBP1; IBP 1; IBP1; IGF binding protein 1; IGF BP25; IGFBP 1; Placental protein 12; PP12. |
| 浓 度 1mg/1ml |
| 规 格 0.1ml/100μg 0.2ml/200μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep |
| 产品类型 一抗 |
研究领域 肿瘤 免疫学 生长因子和激素 转录调节因子 糖尿病  |
| 蛋白分子量 predicted molecular weight: 30kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthetic peptide derived from human IGFBP1 C-terminus |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
| （石蜡切片需做抗原修复） |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.  |
| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 Insulin like growth factor binding protein 1 (IGFBP1) is a member of the superfamily of insulin like growth factor (IGF) binding proteins which include six high affinity IGF binding proteins (IGFBP) and at least four low affinity binding proteins referred to as IGFBP related proteins (IGFBPrP). The IGFBP members are cysteine rich proteins with conserved cysteine residues clustered in the amino terminal and the carboxy terminal regions of the molecule. The N terminal and C terminal regions are highly homologous among rat, human and bovine sequences. Contained within IGFBP1 and 2 is an integrin receptor recognition sequence (RGD) that is responsible for promoting cell migration by an IGF independent action. IGFBPs hold a central position in IGF ligand receptor interactions through influences on both the bioavailability and distribution of IGFs in the extracellular environment. IGFBPs will either inhibit or enhance the biological activities of IGF or act in an IGF independent manner. Post translational modification of IGFBPs, including phosphorylation and proteolysis, will modify the affinities of the binding proteins for IGF and may indirectly regulate IGF actions. IGFBP1 is expressed in liver, decidua, and kidneys and is the major IGF binding protein in human amnionic fluid. In hepatocytes, IGFBP1 production is regulated at the transcriptional level due to the effects of insulin and corticosteriods. IGFBP1 is the major determinant of the level of free IGF in serum. The expression of IGFBP1 is inhibited by insulin, IGFI, and IGFII and is stimulated by glucocorticoids, thyroid hormone, and epidermal growth factor (EGF), indicating an endocrine function. IGFBP1 shows inhibitory actions on cell proliferation and differentiation, presumably by interfering with the interactions between IGF and the IGF receptor (IGFR). |
| Subunit : Binds equally well IGF1 and IGF2. |
| Subcellular Location : Secreted. |
| Similarity : Contains 1 IGFBP N-terminal domain. Contains 1 thyroglobulin type-1 domain. |
| 生长因子和激素（ Growth Factor and Hormones） |
胰岛素样生长因子结合蛋白1(IGFBP-2)是IGF/IGFBP家族中的一个重要成员,在多种疾病尤其是肿瘤中其表达明显增高,可能通过调节胰岛素样生长因子(insulin-like growth factor,IGF)发挥作用，促进肿瘤的发生发展。 |
| Nurr1 核受体相关因子-1（抗原） |
| CD73 (5´-nucleotidase cytosolicⅡ) 胞浆-5´-核苷酸酶-Ⅱ 抗原 |
| OGP (Ostegenic Growth Peptide) 成骨生长肽 (骨生长激素肽)(多肽) |
| OPN 骨桥蛋白（多肽抗原） |
| P53 肿瘤抑制基因（抗原） |
| PACAP-27/38 腺苷酸环化酶激活肽-27/38（抗原） |
| PACAP-38 腺苷酸环化酶激活肽-38（抗原） |
| PACAP/VIP receptor 腺苷酸环化酶激活肽/血管活性肠肽受体（抗原） |
| PACAP receptor-I 腺苷酸环化酶激活肽受体（抗原） |
| PADI4 (HL-60 PAD)(Protein-arginine deiminase type IV，PADI 4，PAD I4 ) 关节炎相关基因 |
| PDGF-A 血小板源性生长因子-1（抗原） |
| PDGF-B 血小板源性生长因子-B（抗原） |
| PDGF-R-A 血小板源性生长因子受体-A（抗原） |
| PDGF-R-B 血小板源性生长因子受体-B（抗原） |
| PMP-22(Peripheral Myelin Protein) 外周髓鞘蛋白-22 多肽 |
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胰岛素样生长因子结合蛋白1抗体
￥1280 - 1980
