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- 详细信息
- 技术资料
- 供应商：
优利科（上海）生命科学有限公司
- 库存：
100
- 靶点：
详询
- 级别：
科研
- 目录编号：
/
- 克隆性：
多克隆
- 抗原来源：
详见说明书
- 保质期：
1年
- 抗体英文名：
Anti-IL-16/LCF
- 抗体名：
IL-16/LCF抗体
- 标记物：
详询
- 宿主：
兔
- 适应物种：
/
- 免疫原：
见产品详情
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
见产品详情
- 保存条件：
-20℃
- 浓度：
1mg/ml
- 规格：
详询
| 英文名称 Anti-IL-16/LCF |
| 中文名称 白介素-16抗体 |
| 别 名 Interleukin-16; HGNC:5980; HsT19289; Interleukin 16 precursor; LCF; Lymphocyte Chemotactic Factor; IL16; Lymphocyte chemoattractant factor; PrIL16; IL16_HUMAN. |
| 浓 度 1mg/1ml |
| 规 格 0.1ml/100μg 0.2ml/200μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Mouse, Rat |
| 产品类型 一抗 |
研究领域 免疫学  |
| 蛋白分子量 predicted molecular weight: 76/141kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthetic peptide derived from mouse IL-16 C-terminus |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
| （石蜡切片需做抗原修复） |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.  |
| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 IL16 is a proinflammatory cytokine that is chemotactic for CD4+ T lymphocytes, monocytes, and eosinophils. IL16 is synthesized as a precursor molecule (pro IL16) of approximately 68 kDa and 631 amino acid residues lacking a signal peptide. The sequence and structure of IL16 is conserved across species. In addition to inducing chemotaxis, IL16 upregulates the IL2 receptor and upregulates HLADR expression. It also inhibits T cell receptor (TCR)/CD3 dependent activation, and suppresses HIV1 replication in vitro. Sources of IL16 include epithelial cells, mast cells, T lymphocytes (CD4+ and CD8+), macrophages, synovial fibroblasts, and eosinophils. |
| Function : Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. |
| Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane. |
| Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
| Subunit : Homotetramer (Probable). According to PubMed:9699630, the formation of a homotetrameric protein complex is not required for the chemo-attractant function. Isoform 3 interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Isoform 1 interacts with PPP1R12B. Isoform 3 interacts with GRIN2A. Isoform 3 interacts with GABPB1. Isoform 3 interacts (via PDZ 3 domain) with HDAC3. Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and CACNA1C. Isoform 3 interacts with HTLV-1 tax. |
| Subcellular Location : Interleukin-16: Secreted. Isoform 1: Cytoplasm. Isoform 3: Cytoplasm. Nucleus. |
| Tissue Specificity : Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation. |
| Post-translational modifications : Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16. |
| Similarity : Contains 4 PDZ (DHR) domains. |
| Database links : UniProtKB/Swiss-Prot: O54824.3 |
| 生长因子和激素（ Growth Factor and Hormones） |
| 白介素16(IL-16)过去称之为淋巴细胞趋化因子(Lymphocyte Chemotactic Factor， LCF)，IL-16具有重要的免疫调节作用,与许多疾病的发生有关。 |
IL-16是三种重要的细胞因子之一（IL-17、TNF-α）,分别参与多种疾病的免疫反应和炎症过程。 |
| Anti-Nogo-A 轴索过度生长抑制因子-A抗体 |
| Anti-Nogo-B 轴索过度生长抑制因子-B抗体 |
| Anti-NOS-1/bNOS/neuronal NOS/nNOS(Nitric Oxide synthase-1） yi氧化氮合成酶-1抗体（神经型） |
| Anti-NOS-2/iNOS (Nitric Oxide Synthase,Inducible) yi氧化氮合成酶-2抗体（诱导型） |
| Anti-NOS-3/eNOS (endotheli cell NOS) yi氧化氮合成酶-3抗体（内皮型） |
| Anti-Nox-4/NADH（NADPH oxidase 4） NADPH氧化酶4抗体 |
| Anti-NPPC (pro-natriuretic peptide) 促尿钠排泄肽前体C抗体 |
| Anti-NPY Neuropeptide Y） 神经肽 Y抗体 |
| Anti-NPY1R (neuropeptide Y1 receptor) 神经肽Y1受体抗体 |
| Anti-NR1/NMDAR1（N-Methyl-d-Asprtate receptor 1） 谷氨酸受体1抗体 |
| Anti-NR2A/NMDAR2A（Glutamate receptor2A） 谷氨酸受体2A抗体（N端） |
| Anti-NR2B/NMDAR2B（N-Methyl-d-Asprtate receptor 2B） 谷氨酸受体2B抗体 |
| Anti-NR2C/NMDAR2C（N-Methyl-d-Asprtate receptor 2C） 谷氨酸受体2C抗体 |
| Anti-NR2D/NMDAR2D（N-Methyl-d-Asprtate receptor 2D） 谷氨酸受体2D抗体 |
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白介素-16抗体
￥1280 - 1980
