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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
优利科（上海）生命科学有限公司
- 库存：
100
- 靶点：
详询
- 级别：
科研
- 目录编号：
/
- 克隆性：
多克隆
- 抗原来源：
详见说明书
- 保质期：
1年
- 抗体英文名：
Anti-Integrin beta 3/CD61
- 抗体名：
Integrin beta 3/CD61抗体
- 标记物：
详询
- 宿主：
兔
- 适应物种：
/
- 免疫原：
见产品详情
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
见产品详情
- 保存条件：
-20℃
- 浓度：
1mg/ml
- 规格：
详询
| 英文名称 Anti-Integrin beta 3/CD61 |
| 中文名称 整合素β3抗体 |
| 别 名 Integrin beta chain, β3 precursor; Integrin Beta 3; CD 61; CD61; CD61 antigen; GP3A; GPIIIa; HPA 1; HPA 4; Integrin beta 3 (platelet glycoprotein IIIa antigen CD61); Integrin beta chain beta 3; ITG B3; ITGB 3; ITGB3; NAIT; Platelet fibrinogen receptor beta subunit; Platelet glycoprotein IIIa; platelet glycoprotein IIIa precursor; Platelet membrane glycoprotein IIIa; PTP; ITB3_HUMAN. |
| 浓 度 1mg/1ml |
| 规 格 0.1ml/100μg 0.2ml/200μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Human, Mouse, Pig, Cow, Rabbit, Bovine |
| 产品类型 一抗 |
研究领域 细胞生物 免疫学 信号转导 干细胞 细胞粘附分子  |
| 蛋白分子量 predicted molecular weight: 84kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthetic peptide derived from human Integrin beta 3 |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 |
| （石蜡切片需做抗原修复） |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.  |
| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 The ITGB3 (Integrin beta chain beta 3) protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. |
| Function : Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. |
| Subunit : Heterodimer of an alpha and a beta subunit. Beta-3 associates with either alpha-IIb or alpha-V. Isoform Beta-3C interacts with FLNB. Interacts with COMP. Interacts with HIV-1 Tat. Interacts with PDIA6 following platelet stimulation. Interacts with SYK; upon activation by ITGB3 promotes platelet adhesion. Interacts with MYO10. |
| Subcellular Location : Membrane; Single-pass type I membrane protein. |
| Tissue Specificity : Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis. |
| Post-translational modifications : Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding. |
| DISEASE : Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors. |
| Similarity : Belongs to the integrin beta chain family. Contains 1 VWFA domain. |
| Database links : UniProtKB/Swiss-Prot: P05106.2 |
| Entrez Gene: 3690 Human |
| Entrez Gene: 16416 Mouse |
| Entrez Gene: 29302 Rat |
| Omim: 173470 Human |
| SwissProt: P05106 Human |
| SwissProt: O54890 Mouse |
| Unigene: 218040 Human |
| Unigene: 87150 Mouse |
CD61抗原又称为GP III a，是一种表达于血小板、巨核细胞、单核细胞、巨噬细胞和内皮细胞上的糖蛋白。CD61和CD41构成血小板糖蛋白II b/III b。  |
| Anti-N-cadherin N-钙粘附分子抗体 |
| Anti-N-coR1 （Nuclear receptor co-repressor 1） 核受体辅助抑制因子抗体 |
| Anti-Nephrin Protein 肾病蛋白抗体 |
| Anti-Nestin 巢蛋白/神经上皮干细胞蛋白抗体 |
| Anti-Nestin 巢蛋白/神经上皮干细胞蛋白抗体 |
| Anti-Neurobeachin protein (AKAP550) 蛋白激酶锚定蛋白/激酶固定蛋白抗体 |
| Anti-Neurocan 神经粘蛋白抗体 |
| Anti-Neurofascin-155 神经束蛋白-155 |
| Anti-NF-H（Neurofilament triplet H) 高分子量神经丝蛋白抗体 |
| Anti-NFKBp65(p65 NF-kappa B;p65NFKB) 细胞核因子/k基因结合核因子抗体 |
| Anti-NF-L（Neurofilament triplet L) 低分子量神经丝蛋白抗体 |
| Anti-NF-M (Neurofilament triplet M） 中分子量神经丝蛋白抗体 |
| Anti-NF-κBp50（p50 NF-kappa B;p50NFKB） 细胞核因子50/κ基因结合核因子50抗体 |
| Anti-NGF-R/p75NTR/CD271（p75 Neurotrophin R） 神经生长因子受体抗体 |
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人整合素αVβ3（ITG αⅤβ3） 酶联免疫 分析（ ELISA ） 试剂 盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定人血清，血浆及相关液体样本中 整合素αVβ3（ITG αⅤβ3） 的 含量。 实验原理 ： 本试剂盒应用双抗体夹心法测定 标本 中 人 整合素αV β 3 （ ITG αⅤβ 3 ） 水平。用纯化的抗体包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入 整合素αV β 3 （ ITG αⅤ
整合素家族血小板糖蛋白组 ( β 3 组 ) 和β 7 组 β3亚单位为CD61，分子质量为105kDa，表达于血小板、巨核细胞、单核细胞、Mφ和内皮细胞。CD6l可与CD4l和CD51分别组成血小板糖蛋白ⅡbⅢa(GPⅡbⅢa，αⅡbβ3)和VN受体(αVβ3)。其中的GPⅡbⅢa(CD61／C1341)在血小板受到凝血酶、腺苷二磷酸(ADP)和胶原等刺激活化后，即可与相应配体结合。而CD51／CD61是玻连蛋白受体(VNR)，介导血小板黏附于固相化
Cancer Cell：整合素 αvβ6-TGFβ-SOX4 途径驱动三阴性乳腺癌的免疫逃逸
9 技术，筛选诱导 TNBC 细胞耐受 T 细胞介导的杀伤力的基因。筛选结果显示 SOX4 和 ITGAV 基因赋予肿瘤细胞抵抗 T 细胞介导的细胞毒性的能力。此外，在肿瘤细胞培养中添加活性 TGFβ1，可显著提高肿瘤细胞对 CD8+T 细胞介导的细胞毒性的耐受性。为了进一步探究整合素 αvβ6–TGFβ–SOX4 途径驱动三阴性乳腺癌的免疫逃逸机制。研究团队构建了不具有抗体依赖的细胞介导的细胞毒性作用（ADCC，Fc 区突变）的整合素 αvβ6/8 单克隆抗体。体外实验表明，用整合素 αvβ6
整合素β3抗体
￥1280 - 1980
