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Anti-IKIP
IKIP抗体
详询
兔
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KLH conjugated synthetic peptide derived from human IKIP (265-300aa)
IgG
Lyophilized or Liquid
WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
-20℃
1mg/ml
详询
英文名称 Anti-IKIP |
中文名称 IKK激酶相互作用蛋白抗体 |
别 名 I kappa B kinase interacting protein; IKIP1; IKIP2; IKIP3; IKK interacting protein; IKIP_HUMAN. |
浓 度 1mg/1ml |
规 格 0.2ml/200μg |
抗体来源 Rabbit |
克隆类型 polyclonal |
交叉反应 Human, Mouse, Rat, Cow, Horse, Sheep |
产品类型 一抗 |
研究领域 细胞生物 信号转导 细胞凋亡 激酶和磷酸酶 |
蛋白分子量 predicted molecular weight: 39kDa |
性 状 Lyophilized or Liquid |
免 疫 原 KLH conjugated synthetic peptide derived from human IKIP (265-300aa) |
亚 型 IgG |
纯化方法 affinity purified by Protein A |
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
(石蜡切片需做抗原修复) |
not yet tested in other applications. |
optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产品介绍 IKIP (I kappa B kinase interacting protein)is located on chromosome 12 in close proximity to APAF1 (apoptotic protease-activating factor-1). IKIP was originally cloned from a yeast two hybrid screening as an IKK2 interacting protein. IKIP and APAF1 share a common 488 bp promoter from which the two genes are transcribed in opposite directions, presumably in a co-regulated manner. Three IKIP transcripts are generated by differential splicing and alternative exon usage and show no significant homology to other genes. IKIP is expressed predominantly in the lung, kidney, spleen, thymus and skeletal muscle. Like APAF1, expression of IKIP is enhanced by irradiation, in a p53-dependent manner. When transfected into endothelial cells IKIP promotes apoptosis suggesting that it plays a role in the cell death process as well as NF-kB regulation. |
Function : Target of p53/TP53 with pro-apoptotic function. |
Subcellular Location : Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Isoform 4 deletion of the hydrophobic, or transmembrane region between AA 45-63 results in uniform distribution throughout the cell, suggesting that this region is responsible for endoplasmic reticulum localization. |
Tissue Specificity : Expressed in vein endothelial cells. Isoform 4 is expressed in lung, kidney, spleen, thymus and skeletal muscle. |
Post-translational modifications : Isoform 4 may be phosphorylated at Thr-362 by similarity with mouse isoform 1. |
N-glycosylated. Isoform 4 is glycosylated at Asn-154. |
Database links : UniProtKB/Swiss-Prot: Q70UQ0.1 |
IL-18/IGIF(Interleukin-18) 白细胞介素-18/干扰素γ诱导因子 |
IL-4(Interleukin-4) 白介素4抗原 |
Inhibin α 抑制素α抗原 |
JNK1/3 (c-Jun amino-terminal kinase 1/3) c-Jun氨基末端激酶1/3多肽抗原 |
Klf4 (Kruppel likefactor 4) 肠道内富含的Kruppel样因子抗原 |
L-HDC (L-Histidine decarboxylase) L-组氨酸脱羧酶抗原 |
LFABP/FABP-1(Liver Fatty acid binding protein) 肝脏型脂肪酸结合蛋白抗原 |
LN (laminin) 层粘连蛋白(多肽抗原) |
ACE( ACE, testis-specific isoform precursor) 血管紧张素转换酶(抗原) |
Mac-1 (Mac-1/CR3/CD11b+CD18) 巨噬细胞表面分子抗原 |
MAGE-1 antibody (Melanoma antigen Recognized by T-cells 1) 黑色素瘤相关抗原 |
Maspin (mammary serine protease inhibitor) 抑癌基因抗原 |
Matriptase 蛋白裂解酶(一种新的癌基因)抗原 |
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