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- 2026年01月13日
- WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:50-200
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
优利科（上海）生命科学有限公司
- 库存：
100
- 靶点：
详询
- 级别：
科研
- 目录编号：
/
- 克隆性：
多克隆
- 抗原来源：
详见说明书
- 保质期：
1年
- 抗体英文名：
Anti-IGSF1
- 抗体名：
IGSF1抗体
- 标记物：
详询
- 宿主：
兔
- 适应物种：
/
- 免疫原：
KLH conjugated synthetic peptide derived from human IGSF1
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:50-200
- 保存条件：
-20℃
- 浓度：
1mg/ml
- 规格：
详询
| 英文名称 Anti-IGSF1 |
| 中文名称 抑制素结合蛋白抗体 |
| 别 名 PGSF2; IGCD1; IGDC1; Immunoglobulin like domain containing protein 1; Immunoglobulin superfamily member 1; InhBP; Inhibin binding protein; KIAA0364; p120; Pituitary gland specific factor 2; IGSF1_HUMAN. |
| 浓 度 1mg/1ml |
| 规 格 0.2ml/200μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Human, Mouse, Rat, Dog, Pig, Horse |
| 产品类型 一抗 |
研究领域 肿瘤 信号转导 生长因子和激素 结合蛋白  |
| 蛋白分子量 predicted molecular weight: 80, 144kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthetic peptide derived from human IGSF1 |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:50-200 |
| （石蜡切片需做抗原修复） |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.  |
| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 IGSF1 is a highly glycolylated immunoglobulin domain-containing protein. IGSF1 has been shown to act as a coreceptor in inhibin signaling, however, it does not appear to be a high-affinity inhibin receptor by itself. May reduce or inhibit activin A signaling and is believed to be necessary in the mediation of specific effects of inhibin B on activin-stimulated transcription. IGSF1 has been found to interact with several members of the ACVR family and possibly some members of the BMPR group. There are 3 known isoforms of IGSF1, with 1 and 2 likely being multi-pass membrane proteins. Isoform 3 is believed to be expressed as a secreted form. Expression is high in pancreas, testis and fetal liver, while heart, prostate and small intestine show only moderate expression. IGSF1 may be found at very low levels in brain, muscle, thymus, ovary, colon, fetal lung and fetal kidney. Isoform 3 has been detected in pituitary gland. |
| Function : Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription. |
| Subunit : Interacts with INHA (By similarity). In PubMed:12385827 does not interact with INHA; standard receptor binding assay. Interacts with ACVR1B; the interaction appears to be ligand-dependent as it is diminished by inhibin B and activin A. Interacts with ACVR2A, ACVR2B, ACVRL1 and BMPR1B. Interacts with HECTD1. |
| Subcellular Location : Isoforms 1 and 2: Membrane; Multipass membrane protein (Potential). Isoform 3: Secreted. |
| Tissue Specificity : Highly expressed in pancreas, testis and fetal liver. Moderately expressed in heart, prostate and small intestine. Expressed at very low levels in brain, thymus, ovary, colon, fetal lung and fetal kidney. Expressed in muscle. Isoform 3 is expressed in pituitary gland. |
| Similarity : Contains 12 Ig-like C2-type (immunoglobulin-like) domains. |
Database links : UniProtKB/Swiss-Prot: Q8N6C5.3 |
| GHR (growth hormone receptor) 生长激素受体(抗原) |
| GLUT1(Glucose transporter type 1） 葡萄糖转运蛋白1（抗原） |
| hypothetical protein （LOC55652) hypothetical protein 抗原 |
| HCCR-1(BRI3 binding protein) 人宫颈癌基因/bri3结合蛋白(抗原) |
| pre S1/S2 protein [HBV] 乙肝病毒pre S1/乙肝病毒pre S2(抗原) |
| HCV-HCBP1/ACY-3(Hepatitis C virus core-binding protein 1) 丙型肝炎病毒核心蛋白结合蛋白-1（抗原） |
| HHV8/ORF50(Human herpesvirus 8 type P) 人类疱疹病毒8抗原 |
| HHV8/ORF K2/vIL-6(Human herpesvirus 8) 人类疱疹病毒8抗原 |
| HIF-1α （Hypoxia-inducible factor -1α） 缺氧诱导因子1α （抗原） |
| HIV gp41 艾滋病病毒（抗原） |
| histone H3-like protein 抗组蛋白H3样抗原 |
| histone H3-like protein 抗组蛋白H3样蛋白（C端抗原） |
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文献和实验或双氢睾酮结合后，转运至曲线精管，提高雄激素在曲细精管的局部浓度，有利于生精过程；②刺激生殖器官的生长发育，促进男性副性征出现并维持其正常状态；③维持正常的性欲；④促进蛋白质合成，特别是肌肉和生殖器官的蛋白质合成，同时还能促进骨骼生长与钙磷沉积和红细胞生成等。 2．抑制素（inhibin）是睾丸支持细胞分泌的糖蛋白激素，由α和β两个亚单位组成，分子量为31000-32000。抑制素对腺垂体的FSH分泌有很强的抑制作用，而同样生理剂量的抑制素对LH分泌却无明显影响。 二、睾丸功能的调节
一、原理： 免疫共沉淀（co-immunoprecipitation，Co-IP）技术是检测蛋白质间相互作用的经典方法,基本原理是以细胞内源性靶蛋白为诱饵，将靶蛋白抗体与细胞总蛋白进行共孵育，促进免疫复合物的形成；随后加入能够与抗体Fc段结合的proreinA/G（预先结合固化在琼脂糖小珠上），形成“结合蛋白-靶蛋白-靶蛋白抗体-proteinA/G小珠”复合物，纯化该复合物后凝胶电泳分离蛋白，应用Westernblot或者质谱技术鉴定靶蛋白的结合蛋白。 与其它研究方法相比，免疫
的 抑制素B （ INHB ） 抗体结合，形成抗体- 抗原 - 酶标抗体复合物 ，经过彻底洗涤后 加 底物TMB 显色。 TMB 在 HRP 酶的催化下转化成蓝色，并在酸的作用下转化成最终的黄色。颜色的深浅和样品中的 抑制素B （ INHB ） 呈正相关。用酶标仪在 450 nm波长下测定吸光度（ OD 值）， 通过标准曲线 计算样品 中人 抑制素B （ INHB ） 浓度。 试剂盒组成 ： 试剂盒组成
