KLH conjugated synthetic peptide derived from human APG4B(Acetyl K39)
亚型:
IgG
形态:
Liquid
应用范围:
IHC-P=1:400-800 (石蜡切片需做抗原修复)
保存条件:
-20℃
浓度:
1mg/ml
规格:
50ul
中文名称:乙酰化自噬相关蛋白4B抗体
英文名称:APG4B(Acetyl K39)
别 名:APG4B (Ac-Lys39); APG4B (Acetyl Lys39); APG4B (Ac-K39); APG4B; ATG4 autophagy related 4 homolog B (S. cerevisiae); AUT like 1 cysteine endopeptidase; AUTL1; Autophagin 1; Autophagy related cysteine endopeptidase 1; Autophagy related protein 4 homolog B; Cysteine protease ATG4B; hAPG4B; MGC1353br; ATG4B_HUMAN.
货号:YLK-KT0698
分 子 量:44kDa
细胞定位:细胞浆
纯化方法:affinity purified by Protein A
储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
产品介绍:ATG4B 是自噬所需的半胱氨酸蛋白酶,可切割 MAP1LC3、GABARAPL2 或 GABARAP 的 C 末端部分,从而释放 I 型。I 型的亚群随后转化为更小的形式(II 型)。 具有显露 C 末端甘氨酸的形式 II 被认为是磷脂酰乙醇/胺 (PE) 缀合形式,并具有与自噬体结合的能力。
Function: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
Subcellular Location: Cytoplasm (Probable).
Tissue Specificity: Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas.