- ￥1280 - 1980
- YLKBIO
- YLK-KT2161D
- 国产/进口
- 2025年07月12日
- WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
- 兔
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
优利科（上海）生命科学有限公司
- 库存：
100
- 靶点：
详询
- 级别：
科研
- 目录编号：
/
- 克隆性：
多克隆
- 抗原来源：
详见说明书
- 保质期：
1年
- 抗体英文名：
Anti-IKB zeta/MAIL protein
- 抗体名：
IKB zeta/MAIL protein抗体
- 标记物：
详询
- 宿主：
兔
- 适应物种：
/
- 免疫原：
KLH conjugated synthetic peptide derived from human IKB zeta/MAIL protein
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
- 保存条件：
-20℃
- 浓度：
1mg/ml
- 规格：
详询
| 英文名称 Anti-IKB zeta/MAIL protein |
| 中文名称 KB抑制蛋白激酶Ζ抗体 |
| 别 名 I-kappa-B-zeta; Ikappa B zeta; IkappaBzeta; IkB-zeta; IKBZ; IKBZ_HUMAN; IKBzeta; IL-1 inducible nuclear ankyrin-repeat protein; INAP; MAIL; MAIL protein; Molecule possessing ankyrin repeats induced by lipopolysaccharide; NF-kappa-B inhibitor zeta; NFKBIZ; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor zeta. |
| 浓 度 1mg/1ml |
| 规 格 0.2ml/200μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep |
| 产品类型 一抗 |
研究领域 细胞生物 免疫学 细胞凋亡 细胞周期蛋白 转录调节因子 激酶和磷酸酶  |
| 蛋白分子量 predicted molecular weight: 78kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthetic peptide derived from human IKB zeta/MAIL protein |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
| （石蜡切片需做抗原修复） |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.  |
| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis. |
| Function : Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity). |
| Subunit : Interacts with NFKB1/p50. Interacts with RELA. |
| Subcellular Location : Nucleus. Note=Aggregated in dot-like structures. Colocalizes with NCOR2. |
| Tissue Specificity : Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart. |
| Similarity : Contains 7 ANK repeats. |
Database links : UniProtKB/Swiss-Prot: Q9BYH8.1 |
| GDNF (Glial cell line-derived neurotrphic factor) 胶质细胞源性神经营养因子抗原 |
| GFP (Green Fluorecent protein) 绿色荧光蛋白多肽抗原 |
| GROα/GRO/MGSA/CXCL1 protein (growthregulated oncogene α) 生长调节致癌基因α/黑素瘤生长刺激因子α 抗原 |
| Haase(hyaluronidase) 透明质酸酶/玻璃酸酶抗原 |
| HA tag HA tag标签蛋白 |
| HBA1（hemoglobin alpha 1） 人类血红蛋白α1抗原 |
| HHV8/ORF50(Human herpesvirus 8 type P) 人类疱疹病毒8抗原 |
| HHV8/ORF50(Human herpesvirus 8 type P) 人类疱疹病毒8抗原 |
| HHV8/ORF K2(Human herpesvirus 8 type P) 人类疱疹病毒8抗原 |
| anti-HMGA1 (high mobility group AT-hook 1) 高迁移率族蛋白A1抗原 |
| HMGA2 (high mobility group A2) 高迁移率族蛋白A2抗原 |
| HO-1/HSP32 (Hemeo xygenase 1) 血红素氧合酶-1/热休克蛋白-32抗原 |
| YT-0662 BCRP/ABCG2（breast cancer resistance protein) 乳腺癌耐药相关蛋白（抗原） |
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文献和实验于JNK，而影响细胞的凋亡。 请各位高手指点一下 您所讲的问题即为在氧化应激的过程中JNK通路的“cross-talk”问题。目前研究的比较多的是有关氧化应激的过程中NF-kb通路通过其靶基因XIAP 和 GADD45对JNK起抑制效应（如图）。此外，还有研究指出，在氧化应激引起的凋亡过程中，MAPKs通路本身的一些激酶（如MKP1，3，5，7）也对JNK起抑制作用。 我知道的很有限，欢迎其他战友补充。
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