- ￥1280 - 1980
- YLKBIO
- YLK-KT2142D
- 国产/进口
- 2026年01月13日
- WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
- 兔
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
优利科（上海）生命科学有限公司
- 库存：
100
- 靶点：
详询
- 级别：
科研
- 目录编号：
/
- 克隆性：
多克隆
- 抗原来源：
详见说明书
- 保质期：
1年
- 抗体英文名：
Anti-IKZF3
- 抗体名：
IKZF3抗体
- 标记物：
详询
- 宿主：
兔
- 适应物种：
/
- 免疫原：
KLH conjugated synthetic peptide derived from human IKZF3 corresponding to amino acids 251-300.
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
- 保存条件：
-20℃
- 浓度：
1mg/ml
- 规格：
详询
| 英文名称 Anti-IKZF3 |
| 中文名称 锌指蛋白Aiolos抗体 |
| 别 名 Aiolos; IKAROS family zinc finger 3 (Aiolos); IKAROS family zinc finger 3; Ikaros family zinc finger protein 3; IKZF 3; IKZF3; IKZF3_HUMAN; Zinc finger protein Aiolos; Zinc finger protein subfamily 1A 3 (Aiolos); Zinc finger protein subfamily 1A 3; ZNFN1A3. |
| 浓 度 1mg/1ml |
| 规 格 0.2ml/200μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit |
| 产品类型 一抗 |
研究领域 染色质和核信号 信号转导 表观遗传学  |
| 蛋白分子量 predicted molecular weight: 58kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthetic peptide derived from human IKZF3 corresponding to amino acids 251-300. |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
| （石蜡切片需做抗原修复） |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
| 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.  |
| 产品介绍 IKZF3 belongs to the Ikaros family of zinc-finger proteins. Members of this family are transcription factors that play an important role in the regulation of lymphocyte differentiation. They are involved in the control of gene expression and when associated with nuclear complexes, participate in nucleosome remodeling. IKZF3 is important in the regulation of B lymphocyte proliferation and differentiation. |
| Function : Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. |
| Subunit : Homodimer, and heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5. Interacts with IKZF1. Interacts with HRAS. Interacts with FOXP3; this interaction may be required for silencing target genes and regulating the suppressive activity of FOXP3-positive regulatory T-cells (Treg). Interacts with BCL21L isoform Bcl-X(L); this interaction blocks the anti-apoptotic role of BCL21L. Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A. |
| Subcellular Location : Nucleus. Cytoplasm. |
| Tissue Specificity : Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus. |
| Post-translational modifications : Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells. |
| Similarity : Belongs to the Ikaros C2H2-type zinc-finger protein family. |
| Contains 6 C2H2-type zinc fingers. |
Database links : UniProtKB/Swiss-Prot: Q9UKT9.2 |
| Anti-P63 protein P63 肿瘤抑制基因抗体 |
| Anti-PACAP/VIP receptor 腺苷酸环化酶激活肽受体-II/血管活性肠肽受体-II抗体 |
| Anti-PACAP/VIP receptor-I 腺苷酸环化酶激活肽受体-I/血管活性肠肽-I抗体 |
| Anti-PACAP-27/38 腺苷酸环化酶激活肽-27/38抗体 |
| Anti-PACAP-38 腺苷酸环化酶激活肽-38抗体 |
| Anti-PADI4/PAD4(Protein-arginine deiminase type IV) Anti-PADI4/PAD4(Protein-arginine deiminase type IV) 关节炎相关基因抗体 |
| Anti-PAF (platelet-activating factor) 血小板活化因子抗体 |
| anti-PALB2(partner and locaizer of BYTA2) 乳腺癌易感基因相关蛋白2 |
| Anti-PANDER/FAM3A 胰腺衍生因子抗体 |
| Anti-PAP2c (Phosphatidic acid phosphatase 2c) 磷脂酸磷酸酶2C抗体 |
| Anti-PAR-1 (Protease-activated receptors-1) 蛋白酶激活受体-1抗体 |
| Anti-PAR-2 (Protease-activated receptors-2) 蛋白酶激活受体-2抗体 |
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文献和实验细胞)提供抗原；B．生发中心F脱结合的抗原-抗体复合物在淋巴结中长期存留，有助于该抗原特异性记忆细胞的存活与维持。 胸腺微环境也可提供浆细胞长期成活的信号和成分，如基质细胞、细胞因子IL-6和迟现抗原VLA-4，另外还有IL-5、TNF-a、SDF-1、CD44和BCMA等的参与，以及转录因子Aiolos等发挥作用。在胸腺微环境中，骨髓浆细胞可高表达抗凋亡分子Bcl-2，A20和IAP-2。
于骨髓中的记忆性B细胞能以抗原非依赖方式产生长寿性浆细胞，由后者分泌特异性的抗体。上文提到，抗天花疫苗的特异性抗体可存在60余年，如何解释?近来发现，胸腺微环境可提供浆细胞长期存活的信号，包括基质细胞、IL-6和迟现抗原VLA- 4，另外还有IL-5、TNF-a、SDF-1、CD44和BCMA等参与，以及转录因子Aiolos等发挥作用。在胸腺微环境中，骨髓浆细胞高表达抗凋亡分子Bcl-2、A20和IAP-2。记忆性B细胞和浆细胞的产生 记忆性B细胞以抗原非特异
的Morrissey博士课题组和加拿大渥太华干细胞研究中心的Brand教授课题组合作在Cell Stem Cell发表了通过单细胞蛋白质组学的方法，测定造血干细胞转录因子共表达谱系的时间特异性变化，首次直接提供了造血干细胞命运决定的蛋白质表达数据。研究人员首先对多能干细胞（CD34+ HSPC）分化为红细胞的完整进程（共22天，包括各个进程的红细胞）定时取样（每隔两天）, 在每个时间点对每个单细胞进行标记，通过27种抗体联合标记对应的蛋白质，再通过质谱流式细胞术（CyTOF)同时测定多种蛋白质的表达，这样科学
