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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
优利科(上海)生命科学有限公司
- 库存:
100
- 靶点:
详询
- 级别:
科研
- 目录编号:
/
- 克隆性:
多克隆
- 抗原来源:
详见说明书
- 保质期:
1年
- 抗体英文名:
Anti-IFIT3
- 抗体名:
IFIT3抗体
- 标记物:
详询
- 宿主:
兔
- 适应物种:
/
- 免疫原:
见产品详情
- 亚型:
IgG
- 形态:
冻干或液体
- 应用范围:
见产品详情
- 保存条件:
-20℃
- 浓度:
1mg/ml
- 规格:
详询
| 英文名称 Anti-IFIT3 |
| 中文名称 干扰素诱导的三角形四肽重复蛋白3抗体 |
| 别 名 CIG 49; CIG49; GARG 49; IFI-60K; IFI60; IFI60K; IFIT-3; IFIT-4; IFIT-3; Ifit3; IFIT3_HUMAN; IFIT4; Interferon induced 60 kDa protein; Interferon induced protein with tetratricopeptide repeats 3; Interferon-induced 60 kDa protein; Interferon-induced protein with tetratricopeptide repeats 3; Interferon-induced protein with tetratricopeptide repeats 4; IRG2; ISG-60; ISG60; P60; Retinoic acid induced gene G protein; Retinoic acid-induced gene G protein; RIG G; RIG-G; RIGG; RP11-149I23.4. |
| 浓 度 1mg/1ml |
| 规 格 0.2ml/200μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Human, Mouse, Rat |
| 产品类型 一抗 |
研究领域 细胞生物 细胞因子 ![]() |
| 蛋白分子量 predicted molecular weight: 56kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthetic peptide derived from human IFIT3 |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 |
| (石蜡切片需做抗原修复) |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. ![]() |
| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
| Function : IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. |
| Subunit : Component of an interferon-dependent multiprotein complex, at least composed of IFIT1, IFIT2 and IFIT3. Interacts with IFIT1 and IFIT2. Interacts (via N-terminus) with MAVS, TBK1, TRAF6 and DDX58. Interacts with COPS5. |
| Subcellular Location : Cytoplasm. Mitochondrion. |
| Tissue Specificity : Expression significantly higher in peripheral blood mononuclear cells (PBMCs) and monocytes from systemic lupus erythematosus (SLE) patients than in those from healthy individuals (at protein level). Spleen, lung, leukocytes, lymph nodes, placenta, bone marrow and fetal liver. |
| Similarity : Belongs to the IFIT family. |
| Contains 8 TPR repeats. |
Database links : UniProtKB/Swiss-Prot: O14879.1![]() |
| ShK(Stichodactyla helianthus Neurotoxin)-(Ala22) 海葵神经毒素(35肽) |
| ShK(Stichodactyla helianthus Neurotoxin)-(Arg22) 海葵神经毒素(35肽) |
| ShK(Stichodactyla helianthus Neurotoxin)-(Dap22) 海葵神经毒素(35肽) |
| ShK(Stichodactyla helianthus Neurotoxin)-(Gln9) 海葵神经毒素(35肽) |
| ShK(Stichodactyla helianthus Neurotoxin)-(Gln11) 海葵神经毒素(35肽) |
| rHBcAg 重组乙肝病毒核心抗原 |
| rHBeAg 重组乙肝病毒e抗原 |
| rDen(rh-Dengue Virus) 多价重组人登革热病毒诊断抗原 |
| Peptide products 多肽抗原(肽库) |
| AAT(Alpha-1antitiypsin) α-1抗胰蛋白酶(抗原) |
| ACEI (Angiotensin I Converting Enzyme Inhibitor ) 血管紧张素1转换酶抑制剂(抗原) |
| Acinus (Apoptotic chromatin condensation Inducer in the nucleus)(抗原) |
| ACTH (Adrenorticotrophin hormons)(7-23) 促肾上腺皮质激素(7-23)(抗原) |
| Actin 肌动蛋白(抗原) |
| β-Actin(暂不销售) 肌动蛋白(抗原)(暂不销售) |
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