- ￥1280 - 1980
- YLKBIO
- YLK-KT2021D
- 国产
- 2025年07月13日
- ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
- Rabbit
- /
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
优利科（上海）生命科学有限公司
- 库存：
99
- 靶点：
详询
- 级别：
科研
- 目录编号：
/
- 克隆性：
多克隆
- 抗原来源：
详见说明书
- 保质期：
1年
- 抗体英文名：
Anti-IP3
- 抗体名：
IP3抗体
- 标记物：
详询
- 宿主：
Rabbit
- 适应物种：
/
- 免疫原：
KLH conjugated synthetic peptide derived from human IP3
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
- 保存条件：
-20℃
- 浓度：
1mg/ml
- 规格：
详询
| 英文名称 Anti-IP3 |
| 中文名称 三磷酸肌醇抗体 |
| 别 名 Type 1 inositol 1 4 5 trisphosphate receptor; Type 1 inositol 1; Type 1 InsP3 receptor.; 5-trisphosphate receptor; 5-trisphosphate receptor type 1; DKFZp313E1334; DKFZp313N1434; inositol 1 4 5 triphosphate receptor type 1; Inositol 1 4 5 trisphosphate Receptor Type 1; Inositol 1; Inositol 145-trisphosphate Receptor Type 1; InsP3R1; IP3; IP3 receptor; IP3 receptor isoform 1; IP3R 1; IP3R; IP3R1; ITPR 1; Itpr1; ITPR1_HUMAN; SCA15; SCA16; SCA29. |
| 浓 度 1mg/1ml |
| 规 格 0.2ml/200μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep |
产品类型 一抗  |
| 研究领域 肿瘤 细胞生物 信号转导 细胞凋亡 新陈代谢 |
| 蛋白分子量 predicted molecular weight: 314kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthetic peptide derived from human IP3 |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
| 产品应用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 |
| （石蜡切片需做抗原修复） |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
| 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4,5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1,4,5- triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver. |
| Function : Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. |
Subunit : Homotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channel activity. The strength of this interaction inversely correlates with calcium concentration. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1. Interacts with AHCYL1 (By similarity). Interacts with MRVI1 and CABP1 (via N-terminus).  |
| Subcellular Location : Endoplasmic reticulum membrane. |
| Tissue Specificity : Widely expressed. |
| Post-translational modifications : Phosphorylated by cAMP kinase. |
| Phosphorylation prevents the ligand-induced opening of the calcium channels. |
| Phosphorylated on tyrosine residues. |
| DISEASE : Defects in ITPR1 are the cause of spinocerebellar ataxia type 15 (SCA15) (SCA15) [MIM:606658]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA15 is an autosomal dominant cerebellar ataxia (ADCA). It is very slow progressing form with a wide range of onset, ranging from childhood to adult. Most patients remain ambulatory. |
| Similarity : Belongs to the InsP3 receptor family. |
| Contains 5 MIR domains. |
Database links : UniProtKB/Swiss-Prot: Q14643.2 |
| MAG-a/b (Myelin associated glycoprotein; L / S -MAG;) 髓鞘相关糖蛋白a/b(抗原) |
| MAG (Myelin associated glycoprotein; L-MAG;MAG-a ) 髓鞘相关糖蛋白(抗原) |
| MAG-a (Myelin associated glycoprotein; L-MAG; ) 髓鞘相关糖蛋白-a(抗原) |
| MMP-1(Mous ematrix metalloproteinases-1) 基质金属蛋白酶-1（小鼠抗原） |
| midnolin isoform Protein 1 中脑核仁蛋白1（抗原） |
| midnolin isoform Protein 2 中脑核仁蛋白2（抗原） |
| MICA(MHC class I polypeptide-related sequence A) 一种细胞应激分子抗原 |
| MRP3(Multidrug Resistanec-Associated Protein 3) 多药耐药相关蛋白3(抗原) |
| MRP1(Multidrug Resistanec-Associated Protein 1) 多药耐药相关蛋白1(抗原) |
| LRP/MVP (Lung resistance related protein) 肺耐药相关蛋白(抗原) |
| MSLN(mesothelin) 间皮素(多肽抗原) |
| MSH2 (mutS homolog 2) MSH2抗原 |
| NKR(Neuromedin B Receptor) 神经激肽B受体（抗原） |
| NF-L（Neurofilament triplet L) 低分子量神经丝蛋白（抗原） |
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文献和实验相关实验
小鼠 三磷酸肌醇 (IP3) 酶联免疫 分析（ ELISA ） 试剂 盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定小鼠血清，血浆及相关液体样本中 三磷酸肌醇(IP3) 含量。 实验原理 ： 本试剂盒应用双抗体夹心法测定 标本 中 小鼠 三磷酸肌醇 (IP3) 水平。用纯化的 小鼠 三磷酸肌醇 (IP3) 抗体包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入 三磷酸肌醇 (IP3) ， 再与HRP 标记
的产生及其调节（图8-16）。其中某些磷脂酰肌醇产物主要参与信号传递，如IP3为一种第二信使，引起胞浆内Ca 2+ 浓度升高，激活Ca 2+ 浓度升高，激活Ca 2+ 依赖的蛋白激酶。3，4-二磷酸磷脂酰肌醇[phosphatidylinositol3，4-bisphosphate,PtdIns(3,4)P2]及3，4，5-三磷酸磷脂酰肌醇[PtdIns(3,4,5)P3]均可以充当第二信使，在体外可激活PKCζ异型。
PKC系统(protein kinase C system，PKC system)
( diacylglycerol, DAG)和1,4,5-三磷酸肌醇(IP3)。IP3动员细胞内钙库释放Ca2 到细胞质中与钙调蛋白结合，随后参与一系列的反应；而DAG在Ca2 的协同下激活蛋白激酶C(protein kinase C，PKC)，然后通过蛋白激酶C引起级联反应，进行细胞的应答, 故此将该系统称为PKC系统,或称为IP3、DAG、Ca2 信号通路。
三磷酸肌醇抗体
￥1280 - 1980
