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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
优利科(上海)生命科学有限公司
- 库存:
63
- 靶点:
/
- 级别:
科研
- 目录编号:
KT0474
- 克隆性:
多克隆
- 抗原来源:
/
- 保质期:
1年
- 抗体英文名:
phospho-AKT3 (Ser472)
- 抗体名:
Rabbit Anti-phospho-AKT3 (Ser472) antibody
- 标记物:
详询
- 宿主:
兔
- 适应物种:
Human, Mouse, Rat, (predicted: Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
- 免疫原:
KLH conjugated Synthesised phosphopeptide derived from human AKT3 around the phosphorylation site of Ser472: QF(p-S)YS
- 亚型:
IgG
- 形态:
Liquid
- 应用范围:
WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
- 保存条件:
-20℃
- 浓度:
1mg/ml
- 规格:
50ul
中文名称:磷酸化蛋白激酶AKT3抗体
英文名称:phospho-AKT3 (Ser472)
别 名:Akt3; AKT3 kinase; AKT3_HUMAN; DKFZp434N0250; PKB gamma; PKBG; PRKBG; Protein kinase Akt-3; Protein Kinase AKT3; Protein kinase B gamma; RAC gamma; RAC gamma serine/threonine protein kinase; RAC-gamma serine/threonine-protein kinase; RAC-PK-gamma; RACPK Gamma; Serine threonine protein kinase Akt 3; Serine threonine protein kinase Akt3; STK 2; STK-2; STK2; V akt murine thymoma viral oncogene homolog 3 protein kinase B gamma.
货号:YLK-KT0474
分 子 量:56kDa
细胞定位:细胞核 细胞浆 细胞膜
纯化方法:affinity purified by Protein A
储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Function:
AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.

注意:
所提供的本产品仅供研究使用,不得用于人类、治疗或诊断应用。


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