Cicaprost

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Cicaprost

CAS No. : 94079-80-8

MCE 国际站：Cicaprost

产品活性：Cicaprost (ZK 96480) 是一种前列环素受体 (IP) 激动剂。Cicaprost可引起动脉的浓度依赖性舒张，EC₅₀ 为 5.8 nM 。

研究领域：GPCR/G Protein

作用靶点：Prostaglandin Receptor

In Vitro: Cicaprost significantly reduces proliferation of human pulmonary artery smooth muscle cells (HPASMC) stimulated by fetal bovine serum (FBS). Cicaprost displays marked antiproliferative activity at 30 nM.
Cicaprost stimulates [³H]cyclic AMP production with EC₅₀ values of 1.5-22 nM, and stimulates [³H]inositol phosphate production (EC₅₀ values 49-457 nM) in all but the SK-N-SH cells.

In Vivo: Cicaprost alters pain perception and inflammatory response in mice lacking prostacyclin receptor. Intravenous injection of Cicaprost (1 μg/kg) causes hypotension of ∼30 mm Hg in anaesthetized wild-type mice.

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