- 询价
- 近岸蛋白(Novoprotein)
- 中国
- DCM95
- 2026年04月28日
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- 详细信息
- 文献和实验
- 技术资料
- 英文名：
Human CEA (诊断原料,肿瘤标志物）
Recombinant Human CEA
Catalog #: DCM95 Derived From: Human Cells
Description:
Recombinant Human CEACAM5/CD66e/CEA is produced by Mammalian expression system and the target gene encoding Lys35-Ala685 is expressed with a 6His tag at the C-terminus.
Accession: NP_004354.3
Names(Known as):Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100; CD66e; CEACAM5
Quality Control:
Mol Mass: 72.4kDa AP Mol Mass: 95-150kDa, reducing conditions
Purity: Greater than 95% as determined by reducing SDS-PAGE.
Formulation:
Supplied as a 0.2 μm filtered solution of PBS, 0.01% Tween 80, pH7.4.
Shipping:
The product is shipped on dry ice pack. Upon receipt, store it immediately at the temperature listed below.
Storage:
Reconstituted protein solution should be stored at ≤ -20°C.
Purification:
Affinity purification chromatography.
Immunoreactivity:
N.A.
Application:
Immunogen, calibrator or standard.
Background:
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin related glycoproteins. They play critical roles in cell–cell recognition. CEACAM5, also called CEA and CD66e, is characterized by having seven extracellular Ig domains and a glycosylphosphatidylinositol (GPI) anchor. CEACAM5 is expressed primarily by epithelial cells, and functions as a calcium-independent adhesion molecule through homophilic and heterophilic interactions with CEACAM1. Studies have shown that CEACAM5 is overexpressed in a majority of carcinomas, and its overexpression can protect tumor cells from apoptosis. It is commonly used as a cancer marker.
FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY
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文献和实验（1）癌胚抗原：癌胚抗原（CEA）常采用ELISA、放射免疫或化学发光法检测。恶性积液CEA明显增高医`学教育网搜集整理。动态检测CEA，并与血清CEA相对照，对恶性肿瘤诊断的符合率可达80%.当积液中CEA＞20μg/L，积液CEA/血清CEA比值＞1.0时，应高度怀疑为恶性积液，且CEA对腺癌所致的积液诊断价值最高。 （2）甲胎蛋白（AFP）：常用ELISA、放射免疫或化学发光法检测AFP.血清AFP对原发性肝癌和胚胎性肿瘤的诊断价值较大。积液中AFP含量与血清浓度呈正相
（一）癌胚抗原（carcinoembryonicantigen，CEA） 癌胚抗原是1965年Gold和Freedman首先从胎儿及结肠癌组织中发现的，CEA是一种分子量为22ku的多糖蛋白复合物，45%为蛋白质。CEA的编码基因位于19号染色体。一般情况下，CEA是由胎儿胃肠道上皮组织、胰和肝的细胞所合成，通常在妊娠前6个月内CEA含量增高，出生后血清中含量已很低下，健康成年人血清中CEA浓度小于2.5μg/L. CEA属于非器官特异性肿瘤相关抗原，分泌CEA的肿瘤大多
、肝细胞癌、肺癌、乳癌以及甲状腺髓质癌的临床监测，亦见于绒毛膜癌、骨癌、前列腺癌和卵巢癌，但无早期诊断价值。 此外，CEA轻度增加也见于某些良性消化道疾病如肠梗阻、胆道梗阻、胰腺炎、肝硬化、结肠息肉、溃疡性结肠炎以及吸烟者和老年人。这些消化道良性疾病患者中25%的人血清CEA可暂时性升高。 癌抗原50（CA50） 正常范围：放射免疫法 小于23000U／L。 检查介绍：癌抗原50是一种以唾液酸酯和唾液酸糖蛋白为主的肿瘤标志物
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