FluA NP Antibody (3C8)
Catalog #: DA074
Spcificty: Antibody recognizes Influenza A Nucleocapsid Protein
Isotype: Mouse IgG1
Source: Cultured in vitro under conditions free from animal derived components.
Product buffer solution: PBS, 350mM NaCl, pH7.4.
Shelf life and storage: 24 months from manufacturing at ≤ -20°C. 1 month, 2 to 8 °C under sterile conditions.
Description: The influenza A virus is the leading cause of annual influenza epidemics and occasional influenza pandemics. NP of influenza A virus plays a central role in viral replication. As a structural protein with no intrinsic enzymatic activity, it is the most abundant viral protein in infected cells. Monomeric NP is a 56 kDa protein with a patch of basic residues capable of binding to a single-strand RNA. NP also contains nuclear localization signals (NLS) and nuclear export signals (NES). The Influenza A virus nucleoprotein (NP) is the major protein component of the genomic viral ribonucleoprotein (vRNP) complexes, which are the replication- and transcription-competent units of Influenza viruses. Early during infection, NP mediates import of vRNPs into the host cell nucleus where viral replication and transcription take place; also newly synthesized NP molecules are targeted into the nucleus, enabling coreplicational assembly of progeny vRNPs.
PARAMETERS TESTED ON EACH LOT
Product appearance: Liquid, may turn slightly opaque during storage.
Product concentration: 5.0 mg/ml (+/- 10 %)
Purity: ≥95 %
Bioactivity-Elisa:
Immobilized Influenza A NP (Cat#DRA130) at 2μg/ml (100 μl/well)can bind FluA NP Antibody 3C8(Cat#DA074).The ED50 of FluA NP Antibody 3C8(Cat#DA074) is 12.62 ng/ml .
FOR RESEARCH OR FURTHER MANUFACTURING USE ONLY